CAS No.120-47-8,Ethylparaben Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	120-47-8
Name:	Ethylparaben
Article Data:	191

Formula:	C₉H₁₀O₃
Molecular Weight:	166.177
Synonyms:	Benzoicacid, p-hydroxy-, ethyl ester (6CI,8CI);4-(Ethoxycarbonyl)phenol;4-Carbethoxyphenol;4-Hydroxybenzoic acid ethyl ester;Aseptin A;Aseptine A;Aseptoform E;Bonomold OE;E 214;Easeptol;Ethyl 4-hydroxybenzoate;EthylButex;Ethyl nipagin;Ethyl p-hydroxybenzoate;Ethyl parasept;Ethylparaben;Mekkings E;Mycocten;p-(Ethoxycarbonyl)phenol;p-Carbethoxyphenol;p-Hydroxybenzoate ethyl ester;
EINECS:	204-399-4
Density:	1.168 g/cm³
Melting Point:	114-117 °C(lit.)
Boiling Point:	297.5 °C at 760 mmHg
Flash Point:	120.3 °C
Solubility:	Soluble in ethanol, ether and acetone, slightly soluble in water
Appearance:	white crystalline powder
Hazard Symbols:	Xi
Risk Codes:	36/37/38
Safety:	26-36-24/25
PSA:	46.53000
LogP:	1.56890

Synthetic route

: 7471-31-0
4-(ethoxycarbonyl)phenyl benzoate

: 120-47-8
Ethyl 4-hydroxybenzoate

Conditions

Conditions	Yield
With sodium; diphenyldisulfane In 1-methyl-pyrrolidin-2-one at 90℃; for 0.5h;	100%
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 100℃; for 3h;	88%
With potassium fluoride; thiophenol In 1-methyl-pyrrolidin-2-one at 100℃; for 1h;	82%

: 56441-55-5
ethyl 4-(benzyloxy)benzoate

: 120-47-8
Ethyl 4-hydroxybenzoate

Conditions

Conditions	Yield
With palladium diacetate; sodium hydride In N,N-dimethyl acetamide at 50℃; for 5h; Inert atmosphere;	99%
With palladium diacetate; sodium hydride In N,N-dimethyl acetamide at 50℃; for 5h; Inert atmosphere;	99%

: 5443-37-8
ethyl 4-(n-prop-2'-enyloxy)benzoate

: 120-47-8
Ethyl 4-hydroxybenzoate

Conditions

Conditions	Yield
With ammonium formate; palladium on activated charcoal In methanol for 0.5h; Heating;	98%

: 105-58-8
Diethyl carbonate

: 99-96-7
4-hydroxy-benzoic acid

: 120-47-8
Ethyl 4-hydroxybenzoate

Conditions

Conditions	Yield
With ethanol; sulfuric acid at 100℃; for 24h; Neat (no solvent); chemoselective reaction;	97.22%

: 64-17-5
ethanol

: 99-96-7
4-hydroxy-benzoic acid

: 120-47-8
Ethyl 4-hydroxybenzoate

Conditions

Conditions	Yield
With sulfuric acid for 5h; Reflux;	97%
With sulfuric acid for 24h; Reflux;	96%
With [1-(3-sulfonic acid)]propyl-3-methylimidazolium hydrogen sulfate at 85 - 100℃; for 3h;	95.8%

: 13031-45-3
ethyl 4-acetoxybenzoate

: 120-47-8
Ethyl 4-hydroxybenzoate

Conditions

Conditions	Yield
With Candida cylindracea lipase In di-isopropyl ether; butan-1-ol at 28 - 30℃; for 14h;	97%
With sodium tetrahydroborate; cobalt(II) chloride In ethanol at 0 - 25℃; for 10h;	94%
With sodium; diphenyldisulfane In 1-methyl-pyrrolidin-2-one at 90℃; for 0.5h;	87%

: 153025-65-1
ethyl (4-tert-butyldimethylsilyloxyphenyl)glyoxylate

: 120-47-8
Ethyl 4-hydroxybenzoate

Conditions

Conditions	Yield
With potassium hydroxide In ethanol at 20℃; for 1.5h;	97%
With sodium phosphate dodecahydrate In N,N-dimethyl-formamide at 20℃; for 2h; chemoselective reaction;	86%
With copper(ll) sulfate pentahydrate In methanol at 100℃; for 0.25h; Microwave irradiation;

: 4334-88-7
p-ethoxycarbonylphenylboronic acid

: 120-47-8
Ethyl 4-hydroxybenzoate

Conditions

Conditions	Yield
With dihydrogen peroxide In water at 30℃; Green chemistry;	97%
With sodium chlorite In water at 20℃; for 0.5h;	90%
With 10-methylacridine-3(10H)-one; oxygen; N-ethyl-N,N-diisopropylamine In water at 20℃; for 24h; Reagent/catalyst; Time; Irradiation; Green chemistry;	88%
With water; oxygen; copper dichloride at 60℃; under 760.051 Torr; for 24h;	67%

: 23676-09-7
ethyl 4-ethoxybenzoate

: 120-47-8
Ethyl 4-hydroxybenzoate

Conditions

Conditions	Yield
With aluminium trichloride In dichloromethane; ethanethiol for 9.5h; Ambient temperature;	95.5%
With aluminium trichloride In dichloromethane; ethanethiol for 9.5h; Ambient temperature;	95.5%
With aluminium trichloride; ethanethiol

: 64-17-5
ethanol

: 201230-82-2
carbon monoxide

: 540-38-5
4-Iodophenol

: 120-47-8
Ethyl 4-hydroxybenzoate

Conditions

Conditions	Yield
With 4 A molecular sieve; (Ph3P)PdCl2 In tetrahydrofuran at 100℃; under 22800 Torr; for 24h;	95%
bis-triphenylphosphine-palladium(II) chloride In various solvent(s) at 100℃; under 22800 Torr; for 24h;	99 % Spectr.

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Chemistry

Empirical Formula: C₉H₁₀O₃
Molecular Weight: 166.1739 g/mol
EINECS: 204-399-4
Index of Refraction: 1.538
Density: 1.168 g/cm³
Flash Point: 120.3 °C
Melting point: 115-118 °C(lit.)
Storage tempreture: 0-6 °C
Appearance: White crystalline powder
Enthalpy of Vaporization: 55.89 kJ/mol
Boiling Point: 297.5 °C at 760 mmHg
Vapour Pressure: 0.000759 mmHg at 25 °C
Solubility: Soluble in ethanol, ether and acetone, slightly soluble in water
Structure of Ethylparaben (CAS NO.120-47-8):

IUPAC Name: Ethyl 4-hydroxybenzoate
Product Category of Ethylparaben (CAS NO.120-47-8): Pharmaceutical Raw Materials;Aromatic Esters

Uses

Ethylparaben (CAS NO.120-47-8) is used as a food preservative, and is also used in the pharmaceutical, leather and other industries.

Production

Ethylparaben (CAS NO.120-47-8) can be obtained from the right-hydroxy benzoic acid and ethanol in the presence of sulfuric acid as catalyst for esterification, after that having them in water for crystallization, and then through filter and pickling to get the product.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
dog	LD50	oral	5gm/kg (5000mg/kg)	FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 81, 1974.
guinea pig	LD50	oral	2gm/kg (2000mg/kg)	FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 81, 1974.
mouse	LD50	intraperitoneal	520mg/kg (520mg/kg)	Drug Standards. Vol. 20, Pg. 89, 1952.
mouse	LD50	oral	3gm/kg (3000mg/kg)	Bromatologia i Chemia Toksykologiczna. Vol. 14, Pg. 301, 1981.
rabbit	LD50	oral	5gm/kg (5000mg/kg)	FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 81, 1974.
rat	LD	oral	> 200mg/kg (200mg/kg)	Acta Obstetrica et Gynaecologica Japonica, English Edition. Vol. 22, Pg. 94, 1975.

Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-24/25
S24/25:Avoid contact with skin and eyes.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.

Specification

Ethylparaben , its cas register number is 120-47-8. It also can be called Ethyl paraben ; 4-(Ethoxycarbonyl)phenol ; Ethyl 4-hydroxybenzoate ; p-Hydroxybenzoate ethyl ester ; Ethyl butex ; 4-Hydroxybenzoic acid ethyl ester ; and Ethyl p-hydroxybenzoate . It is hazardous, so the first aid measures and others should be known. Such as: When on the skin: first, should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Secondly, get medical aid. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Then get medical aid soon. While, it's inhaled: Remove from exposure and move to fresh air immediately. Give artificial respiration while not breathing. When breathing is difficult, give oxygen. And as soon as to get medical aid. Then you have the ingesting of the product: Wash mouth out with water, and get medical aid immediately. Notes to physician: Treat supportively and symptomatically.
In addition, Ethylparaben (CAS NO.120-47-8) is not compatible with strong oxidizing agents, and you must not take it with incompatible materials. And also prevent it to broken down into hazardous decomposition products: carbon monoxide, carbon dioxide.

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