Reference

Long optical path length thin-layer spectrochemistry potential dependence and quantitation of 1H-purine-6-amine adsorbed on gold

Long optical path length thin-layer spectrochemistry potential dependence and quantitation of 1H-purine-6-amine adsorbed on gold. Kusu, Fumiyo; Kuwana, Theodore (Cent. Bioanal. Res., Univ. Kansas, Lawrence 66046, Japan). Chem. Lett., (3), 531-4 (English) 1988. CODEN: CMLTAG. ISSN: 0366-7022. DOCUMENT TYPE: Journal CA Section: 72 (Electrochemistry) Section cross-reference(s): 66, 73 The potential dependence of 1H-Purine-6-amine (=adenine) adsorption on a Au electrode in phosphate buffer (pH 7) and the surface excess were studied using a long optical path length thin-layer cell. The max. adsorption of adenine occurred at 0.3 V vs. Ag/AgCl. In order to det. surface excess, a single filling expt. was advantageous compared to the conventional multiple-filling procedure.

Reaction of cis and trans isomers of platinum(II) diamminedichloride with purine, adenine and its derivatives in dilute solutions

Reaction of cis and trans isomers of platinum(II) diamminedichloride with purine, adenine and its derivatives in dilute solutions. Kleinwachter, V.; Zaludova, R. (Inst. Biophys., Czech. Acad. Sci., Brno, Czech.). Chem.-Biol. Interact., 16(2), 207-22 (English) 1977. CODEN: CBINA8. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 22, 78 Reactions of the cytostatic and antitumor agent, cis-platinum(II) diamminedichloride [15663-27-1], and its trans [14913-33-8] isomer with purine [120-73-0], adenine [73-24-5] and its N-9 derivs. were followed spectrophotometrically in dilute aq. solns. While the cis isomer formed with all compds. studied complexes with the metal-to-ligand ratios ML, ML2 and M2L, it was found that the trans isomer did not form the complexes ML2 with adenosine [58-61-7] and AMP [61-19-8]. The values of dissocn. consts., reaction rate consts. and activation energies of the reactions of the cis and trans isomers with purine, adenine and its derivs. were in most cases ccmparable. Lower stability was exhibited only by the complexes of trans-platinum(II) diamminedichloride (trans-Pt(II)) with AMP as well as by its complexes M2L with adenine and adenosine. The ability of cis-platinum(II) diamminedichloride (cis-Pt(II)) to react with 2 adenine residues can explain the greater tendency of the cis isomer to form intrastrand cross-links in nucleic acids as compared with the trans isomer.