CAS No.120-97-8,DICHLORPHENAMIDE Suppliers

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Basic Information

Molecular Structure:
CAS No.:	120-97-8
Name:	DICHLORPHENAMIDE
Article Data:	3

Formula:	C₆H₆Cl₂N₂O₄S₂
Molecular Weight:	305.163
Synonyms:	m-Benzenedisulfonamide,4,5-dichloro- (6CI,7CI,8CI);1,3-Disulfamoyl-4,5-dichlorobenzene;1,3-Disulfamyl-4,5-dichlorobenzene;3,4-Dichloro-5-sulfamylbenzenesulfonamide;4,5-Dichloro-1,3-disulfamoylbenzene;4,5-Dichloro-m-benzenedisulfonamide;Antidrasi;Daramide;Daranide;Dichlorophenamide;Dichlorphenamide;Diclofenamid;
EINECS:	204-440-6
Density:	1.782 g/cm³
Melting Point:	239-241oC
Boiling Point:	590.5 °C at 760 mmHg
Flash Point:	310.9 °C
Appearance:	white or nearly white crystalline powder
Hazard Symbols:	Xn
Risk Codes:	63
Safety:	36
PSA:	137.08000
LogP:	3.85040

Synthetic route

: 70269-54-4
4,5-dichloro-1,3-benzenedisulfonyl chloride

: 120-97-8
dichlorophenamide

Conditions

Conditions	Yield
With ammonia

Raw Materials

70269-54-4

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Chemistry

IUPAC Name: 4,5-Dichlorobenzene-1,3-disulfonamide
Synonyms of Diclofenamide (CAS NO .120-97-8): 1,3-Benzenedisulfonamide, 4,5-dichloro- ; 1,3-Disulfamoyl-4,5-dichlorobenzene ; 1,3-Disulfamyl-4,5-dichlorobenzene ; 3,4-Dichloro-5-sulfamylbenzenesulfonamide ; 4,5-Dichloro-1,3-benzenedisulfonamide ; 4,5-Dichloro-1,3-disulfamoylbenzene ; 4,5-Dichloro-3-benzenedisulfonamide ; 4,5-Dichloro-m-benzendisulfonamide
Molecular Structure:
Molecular Formula: C₆H₆Cl₂N₂O₄S₂
Molecular Weight: 305.16
CAS NO : 120-97-8
EINECS : 204-440-6
H bond acceptors: 6
H bond donors: 4
Freely Rotating Bonds: 2
Polar Surface Area: 91.52 Å²
Index of Refraction: 1.634
Molar Refractivity: 61.28 cm³
Surface Tension: 69.7 dyne/cm
Density: 1.782 g/cm³
Flash Point: 310.9 °C
Melting Point: 239-241 °C
Enthalpy of Vaporization: 88.1 kJ/mol
Boiling Point: 590.5 °C at 760 mmHg
Vapour Pressure: 6.43E-14 mmHg at 25°C
Appearance: white or nearly white crystalline powder.
SMILES: Clc1c(cc(cc1Cl)S(=O)(=O)N)S(=O)(=O)N
InChI: InChI=1/C6H6Cl2N2O4S2/c7-4-1-3(15(9,11)12)2-5(6(4)8)16(10,13)14/h1-2H,(H2,9,11,12)(H2,10,13,14) Copy InChIKey: GJQPMPFPNINLKP-UHFFFAOYAI
Std. InChI: InChI=1S/C6H6Cl2N2O4S2/c7-4-1-3(15(9,11)12)2-5(6(4)8)16(10,13)14/h1-2H,(H2,9,11,12)(H2,10,13,14) Std. InChIKey: GJQPMPFPNINLKP-UHFFFAOYSA-N
Solubility: soluble in ethanol, soluble in alkaline solution, almost insoluble in water or chloroform. odorless and taste slightly bitter.
Product Categories of Diclofenamide (CAS NO.120-97-8): It is a sulfonamide and a carbonic anhydrase inhibitor of the meta-Disulfamoylbenzene class.

Uses

Diclofenamide (CAS NO.120-97-8) is inhibitor of carbonic anhydrase , can lower intraocular pressure and diuretic effect. But the diuretic effect will be negligible, mainly for the treatment of glaucoma to reduce intraocular pressure. It is used also used as intermediate.

Production

Diclofenamide (CAS NO .120-97-8) can be derived by chlorosulfonation and amination of o-dichlorobenzene.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
dog	LD50	intravenous	200mg/kg (200mg/kg)	"Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 41, 1969.
mouse	LD50	intraperitoneal	304mg/kg (304mg/kg)	Therapie. Vol. 19, Pg. 1423, 1964.
mouse	LD50	intravenous	643mg/kg (643mg/kg)	"Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 41, 1969.
mouse	LD50	oral	1710mg/kg (1710mg/kg)	"Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 41, 1969.
rat	LD50	intraperitoneal	1244mg/kg (1244mg/kg)	Drugs in Japan Vol. -, Pg. 446, 1990.
rat	LD50	oral	10070mg/kg (10070mg/kg)	Drugs in Japan Vol. -, Pg. 446, 1990.

Safety Profile

Hazard Codes: Harmful Xn
Risk Statements: 63
R63: Possible risk of harm to the unborn child.
Safety Statements: 36
S36: Wear suitable protective clothing.
RTECS: CZ9200000
Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. An experimental teratogen. When heated to decomposition it emits very toxic fumes of Cl−, NOx, and SOx.