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120709-09-3

Basic Information
CAS No.: 120709-09-3
Name: (6R,7R)-7-Amino-8-oxo-3-(1-propenyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Molecular Structure:
Molecular Structure of 120709-09-3 ((6R,7R)-7-Amino-8-oxo-3-(1-propenyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid)
Formula:  C10H12N2O3 S
Molecular Weight: 240.283
Synonyms: 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 7-amino-8-oxo-3-(1-propenyl)-, (6R,7R)- (9CI);7 APCA;
EINECS: 601-733-4
Density: 1.5 g/cm3
Boiling Point: 539.275 °C at 760 mmHg
Flash Point: 279.944 °C
PSA: 108.93000
LogP: 0.78180
Synthetic route
75-07-0

acetaldehyde

957-68-6

7-Aminocephalosporanic acid

120709-09-3

(6R,7R)-7-amino-3-(propen-1-yl)-3-cephem-4-carboxylic acid

Conditions
ConditionsYield
Stage #1: 7-Aminocephalosporanic acid With pyridine; 1,1,1,3,3,3-hexamethyl-disilazane In benzene for 2h; Inert atmosphere; Reflux;
Stage #2: With trimethylsilyl iodide In benzene at 0℃; for 1h;
Stage #3: acetaldehyde Reagent/catalyst; Further stages;
84.24%
120709-09-3

(6R,7R)-7-amino-3-(propen-1-yl)-3-cephem-4-carboxylic acid

37763-23-8

D-2-p-hydroxyphenylglycine methyl ester

92665-29-7

7-[2-amino-2-(4-hydroxyphenyl)acetamido]-3-(propen-1-yl)-3-cephem-4-carboxylic acid

Conditions
ConditionsYield
Stage #1: (7R,8R)-7-amino-3-[propen-1-yl]-3-cephem-4-carboxylic acid With penicillin acylase at 30 - 35℃; for 0.5h; pH=7; Enzymatic reaction;
Stage #2: D-2-p-hydroxyphenylglycine methyl ester With sodium lauryl sulfate In 1,4-dioxane at 30 - 35℃; for 2h; Reagent/catalyst;
97.74%
120709-09-3

(6R,7R)-7-amino-3-(propen-1-yl)-3-cephem-4-carboxylic acid

((R)-(2-ethoxycarbonyl-1-methyl-vinylamino)-(4-hydroxyphenyl)-acetyloxy)-(triphenyl)phosphonium chloride

A

121412-77-9

cefprozil

B

92676-86-3

E-cefprozil

Conditions
ConditionsYield
Stage #1: (7R,8R)-7-amino-3-[propen-1-yl]-3-cephem-4-carboxylic acid; ((R)-(2-ethoxycarbonyl-1-methyl-vinylamino)-(4-hydroxyphenyl)-acetyloxy)-(triphenyl)phosphonium chloride With triethylamine In dichloromethane; water at -40 - 0℃; for 3h;
Stage #2: With hydrogenchloride In dichloromethane; water for 1h;
Stage #3: With sodium hydroxide In dichloromethane; water at 0℃; for 2h; pH=3.2;
Stage #1: (7R,8R)-7-amino-3-[propen-1-yl]-3-cephem-4-carboxylic acid; ((R)-(2-ethoxycarbonyl-1-methyl-vinylamino)-(4-hydroxyphenyl)-acetyloxy)-(triphenyl)phosphonium chloride With triethylamine In ISOPROPYLAMIDE; water at -40 - 0℃; for 3h;
Stage #2: With hydrogenchloride In ISOPROPYLAMIDE; water for 1h;
Stage #3: With sodium hydroxide In ISOPROPYLAMIDE; water at 0℃; for 2h; pH=3.2;
120709-09-3

(6R,7R)-7-amino-3-(propen-1-yl)-3-cephem-4-carboxylic acid

A

121412-77-9

cefprozil

B

92676-86-3

E-cefprozil

Conditions
ConditionsYield
Stage #1: potassium (R)-(2-ethoxycarbonyl-1-methyl-vinylamino)-(4-hydroxyphenyl)-acetate With pyridine; pivaloyl chloride In DMF (N,N-dimethyl-formamide); dichloromethane at -30℃; for 2h;
Stage #2: (7R,8R)-7-amino-3-[propen-1-yl]-3-cephem-4-carboxylic acid With triethylamine In DMF (N,N-dimethyl-formamide); dichloromethane; water at -40 - 0℃; for 3h;
120709-09-3

(6R,7R)-7-amino-3-(propen-1-yl)-3-cephem-4-carboxylic acid

C12H17NO5

C22H27N3O7S

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 3h;
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    120709-09-3

    (6R,7R)-7-Amino-8-oxo-3-(1-propenyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

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    120709-09-3

    (6R,7R)-7-Amino-8-oxo-3-(1-propenyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

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  • Lower Price 7-APRA

  • Casno:

    120709-09-3

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    Product name: 7-APRA CAS No.: 120709-09-3 Molecule Formula:C10H12N2O3S Molecule Weight:240.28 Purity: 99.0% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard TESTING

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  • (6R,7R)-7-Amino-8-oxo-3-(1-propenyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

  • Casno:

    120709-09-3

    (6R,7R)-7-Amino-8-oxo-3-(1-propenyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

    Min.Order: 1 Kilogram

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    Tel:13958565781

    Address:Room 623 Yulan Square Bussiness Building . Jiaojiang Taizhou Zhejiang 318000 China

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  • (6R,7R)-7-Amino-8-oxo-3-(1-propenyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

  • Casno:

    120709-09-3

    (6R,7R)-7-Amino-8-oxo-3-(1-propenyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

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  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 7-amino-8-oxo-3-(1-propen-1-yl)-, (6R,7R)-

  • Casno:

    120709-09-3

    5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 7-amino-8-oxo-3-(1-propen-1-yl)-, (6R,7R)-

    Min.Order: 0

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  • (6R,7R)-7-Amino-8-oxo-3-(1-propenyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

  • Casno:

    120709-09-3

    (6R,7R)-7-Amino-8-oxo-3-(1-propenyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

    Min.Order: 1 Metric Ton

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Chemistry

Product Name: 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 7-amino-8-oxo-3-(1-propen-1-yl)-, (6R,7R)-
Systematic of 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 7-amino-8-oxo-3-(1-propen-1-yl)-, (6R,7R)- (CAS NO.120709-09-3): (6R,7R)-7-Amino-8-oxo-3-(1-propenyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid ; 7-APRA
CAS NO: 120709-09-3
Molecular Formula of 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 7-amino-8-oxo-3-(1-propen-1-yl)-, (6R,7R)- (CAS NO.120709-09-3): C10H12N2O3S
Molecular Weight: 240.2789
Molecular Structure:

H bond acceptors: 5
H bond donors: 3
Freely Rotating Bonds: 3
Polar Surface Area: 108.93 Å2
Index of Refraction: 1.685
Molar Refractivity: 60.867 cm3
Molar Volume: 160.139 cm3
Surface Tension: 74.83 dyne/cm
Density of 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 7-amino-8-oxo-3-(1-propen-1-yl)-, (6R,7R)- (CAS NO.120709-09-3): 1.5 g/cm3
Flash Point: 279.944 °C
Enthalpy of Vaporization: 89.317 kJ/mol
Boiling Point: 539.275 °C at 760 mmHg