Detail of "12080-32-9"

Reference

Dendrimer-Phosphine Complexes with Platinum(0) at the Core

Dendrimer-Phosphine Complexes with Platinum(0) at the Core. Balaji, B. S.; Obora, Yasushi; Ohara, Daisuke; Koide, Shigehiro; Tsuji, Yasushi (Catalysis Research Center and Division of Chemistry Graduate School of Science, Hokkaido University, Sapporo 060-0811, Japan). Organometallics, 20(25), 5342-5350 (English) 2001 American Chemical Society. CODEN: ORGND7. ISSN: 0276-7333. DOCUMENT TYPE: Journal CA Section: 29 (Organometallic and Organometalloidal Compounds) Section cross-reference(s): 35, 78 Prepn. of novel mono- and bidentate phosphine ligands having dendrimer moiety is reported. Monodentate (1a-c) (shown as I; R = G1 (1a), R = G2 (1b), R = G3 (1c)) and bidentate ligands (5a,c) (shown as II; R = G1 (5a), R = G2 (5b)) were synthesized from bis(4-hydroxyphenyl)phenylphosphine oxide (3) and 1,2-bis(dichlorophosphino)ethane, resp., in high yields. The defect-free monodisperse nature of these compds. was confirmed by 31P NMR and elemental anal. as well as by ESI mass spectra. Complexation of these ligands with PtCl2(COD) followed by NaBH4 redn. in a THF/H2O mixt. gave Pt(0) complexes PtL3 10a,b (having 1a,b as monodentate ligands (L)) and Pt(L-L)2 (13a,b) (5a,b as bidentate ligands (L-L)), resp. Preliminary studies on oxidative addn. of RI (R = CH3 or C6H5) to 10a,b showed that the metal center is easily accessible. Further, mol. modeling of 13b showed nanoscale flattened globular structure of the complex with an approx. diam. of 4.4 nm. Keywords dendrimer bidentate monodentate phenylphosphine platinum complex prepn platinum core bidentate monodentate phenylphosphine dendrimer complex prepn phosphine bidentate monodentate dendrimer platinum complex prepn oxidative addn iodobenzene iodomethane trisphosphine dendrimer platinum complex mol modeling platinum dendrimer bidentate phosphine complex Index Entries Addition reaction kinetics coordinative, oxidative; of iodomethane or iodobenzene with platinum dendrimer-phosphine ligand contg. complexes Density functional theory PM3 (molecular orbital) mol. modeling and conformational anal. of platinum bidentate dendrimer-phosphine ligand contg. complex using DFT and PM3/MOZYME calcns. Phosphines monodentate and bidentate platinum complexes; prepn. of dendrimer-phosphine complexes with platinum(0) at the core Conformation Molecular modeling of platinum bidentate dendrimer-phosphine ligand contg. complex using DFT and PM3/MOZYME calcns. Molecular structure optimized; of platinum bidentate dendrimer-phosphine ligand contg. complex using DFT and PM3/MOZYME calcns. Addition reaction, coordinative oxidative; of iodomethane or iodobenzene with platinum dendrimer-phosphine ligand contg. complexes Polyphenyls polyether-, dendrimers; prepn. of dendrimer-phosphine complexes with platinum(0) at the core Dendritic polymers polyether-polyphenyl-; prepn. of dendrimer-phosphine complexes with platinum(0) at the core Polyethers, preparation polyphenyl-, dendrimers; prepn. of dendrimer-phosphine complexes with platinum(0) at the core 591-50-4 coordinative oxidative addn. of iodomethane or iodobenzene with platinum dendrimer-phosphine ligand contg. complexes 13517-35-6 coordinative oxidative addn. with iodobenzene or iodomethane 795-43-7 dendrimer core precursor; reaction with Frechet type polybenzyl ether bromide dendrimer unit 129371-31-9, benzyloxy-terminated dendrimers; prepn. of dendrimer-phosphine complexes with platinum(0) at the core 390417-77-3 390800-96-1 prepn. and coordinative oxidative addn. with iodobenzene or iodomethane 390801-95-3 prepn. and mol. modeling and conformational anal. of platinum bidentate dendrimer-phosphine ligand contg. complex using DFT and PM3/MOZYME calcns. 390417-74-0 390417-75-1 prepn. and reaction with bis(dichlorophosphino)ethane 390417-70-6 390417-71-7 390417-72-8 390417-73-9 prepn. and reaction with platinum cyclooctadiene chloride complex 390417-84-2 390417-85-3 prepn. and redn. with trichlorosilane 390417-76-2 390417-79-5 390800-56-3 390801-80-6 prepn. and sodium borohydride redn. to Pt(0) complexes 28850-19-3 53424-01-4 390417-80-8 390417-81-9 390417-82-0 390417-83-1 390802-50-3 390803-44-8 prepn. of 12080-32-9 390417-78-4 390801-05-5 prepn. of dendrimer-phosphine complexes with platinum(0) at the core 24131-32-6 129536-41-0 137472-17-4 reaction of Frechet type polybenzyl ether bromide dendrimer unit with bis(hydroxyphenyl)phenylphosphine oxide 106-41-2 reaction with Frechet type polybenzyl ether bromide dendrimer unit 28240-69-9 reaction with bromophenyl Frechet type polybenzyl ethers

A fluorine containing bipyridine cisplatin analog is more effective than cisplatin at inducing apoptosis in cancer cell lines

All Rights Reserved. A fluorine containing bipyridine cisplatin analog is more effective than cisplatin at inducing apoptosis in cancer cell lines. Elwell, Kyler E.; Hall, Casey; Tharkar, Shweta; Giraud, Yvonne; Bennett, Byron; Bae, Chulsung; Carper, Stephen W. (Chemistry Department, UNLV, Las Vegas, NV 89154-4003, USA). Bioorganic & Medicinal Chemistry, 14(24), 8692-8700 (English) 2006 Elsevier Ltd. CODEN: BMECEP. ISSN: 0968-0896. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 78 Novel cisplatin analogs (I and II) were synthesized and evaluated for their cytotoxicity. 54822-56-9 and 12080-32-9 are also in the experiment. While II was not cytotoxic, I was 14 to 125 times more lethal than cisplatin in breast, prostate, and lung cancer cell lines. Compd. I was able to induce apoptosis and the presence of the platinum atom was essential to its function as a cytotoxin. .