Detail of "121-39-1"

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Study of artificial flavoring substances for mutagenicity in the Salmonella/microsome, Basc and micronucleus tests

Study of artificial flavoring substances for mutagenicity in the Salmonella/microsome, Basc and micronucleus tests. Wild, D.; King, M. T.In this study， 91-62-3 and 104-45-0 are also used.; Gocke, E.; Eckhardt, K. (Zentrallab. Mutagenitaetspruef., Dtsch. Forschungsgemeinsch., Freibrug D-7800, Fed. Rep. Ger.). Food Chem. Toxicol., 21(6), 707-19 (English) 1983. CODEN: FCTOD7. ISSN: 0278-6915. DOCUMENT TYPE: Journal CA Section: 17 (Food and Feed Chemistry) Seventy-six compds. used as artificial flavoring substances in food products were studied for mutagenic properties by the use of the Salmonella/mammalian microsome test (Ames test), Basc test on Drosophilia melanogaster, and micronucleus test on mouse bone marrow. The following 4 compds. were mutagenic in Ames tests. EtNO2 [109-95-5], ethyl 3-phenylglycidate [121-39-1], 6-methylquinoline [91-62-3] and musk ambrette. Of these EtNO2 and musk ambrette also induced an increase in sex-linked recessive lethal mutations in Drosophila. Two further compds. ethyl 3-methyl-3-phenylglycidate [77-83-8] and 4-propylanisole [104-45-0], appeared weakly mutagenic in Drosophila only. The result with 4-propylanisole was of equivocal biol. significance. None of the flavoring substances induced micronuclei, i.e. cytogenetic damage in the bone marrow of mice. .

Investigation of the mutagenicity of ethyl phenylglycidate

Investigation of the mutagenicity of ethyl phenylglycidate. Tilch, C.; Elias, P. S. (Bundesforschungsanst. Ernaehr., Karlsruhe D-7500, Fed. Rep. Ger.). Mutat. Res., 138(1), 1-8 (English) 1984. CODEN: MUREAV. ISSN: 0027-5107. DOCUMENT TYPE: Journal CA Section: 17 (Food and Feed Chemistry) Et phenylglycidate (EPG) [121-39-1] and an in vitro digest of EPG by pepsin and pancreatin simulating mammalian digestion were examd. for genotoxicity in 4 mutagenicity tests employing different genetic endpoints. In the Salmonella reverse mutation assay, EPG showed only slight mutagenic activity against TA100, a strain responsive to base-pair exchange activity, in the presence of S9 mix. In vitro EPG was mutagenic for CHO-K1-BH4 cells with or without metabolic activation, the activity being greater in the presence of metabolic activation. In the in vitro sister chromatid exchange test, EPG was clastogenic for CHO-K1-BH4 cells independent of metabolic activation. EPG also induced transformation of C3H T101/2 mouse fibroblasts in vitro, producing both type II and type III foci. Subjecting an EPG soln. to a simulated mammalian digestion process lowers the genotoxic activity of the soln.