Reference

Terreic acid - a diabetogenic mycotoxin in rats

Terreic acid - a diabetogenic mycotoxin in rats. Shanmugasundaram, E. R. B.; Parameswari, C. S.; Shanmugasundaram, K. Radha (A. C. Coll., Univ. Biochem. Lab., Madras 600 025, India). Curr. Sci., 53(24), 1290-2 (English) 1984. CODEN: CUSCAM. ISSN: 0011-3891. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Rats receiving i.p. injection of 0.2 mg terreic acid (I) [121-40-4]/animal or fed a diet contg. I (daily consumption 50 mg) for a period of 24 wk showed hyperglycemia accompanied with a drastic decrease in the liver glycogen [9005-79-2]. Blood glucose increased. Serum insulin [9004-10-8] levels substantially decreased at fasting levels of glucose and even after glucose administration. Therefore, the toxin might have decreased the insulin secretion by affecting the b-cells.

Interactions of geodin antibiotics and some other naturally occuring a,b-unsaturated carbonyl compounds with low molecular thiols and thiolproteins

Interactions of geodin antibiotics and some other naturally occuring a,b-unsaturated carbonyl compounds with low molecular thiols and thiolproteins. Sturdik, Ernest; Drobnica, Ludovit; Sladkova, Vlasta; Krchnava, Edita (Dep. Tech. Microbiol. Biochem., Slovak Polytech. Univ., Bratislava 812 37, Czech.). Biologia (Bratislava), 38(12), 1229-41 (English) 1983. CODEN: BLOAAO. ISSN: 0006-3088. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Geodin (I) [427-63-4], trypacidin (II) [1900-29-4], plumbagin (III) [481-42-5], terreic acid [121-40-4] and monorden [12772-57-5] were potent inhibitors of glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12) [9001-50-7] and other sulfhydryl (SH) enzymes, glucose-6-phosphate dehydrogenase (EC 1.1.1.49) [9001-40-5], glutathione reductase (EC 1.6.4.2) [9001-48-3] and malate dehydrogenase (EC 1.1.1.37) [9001-64-3]. The expts. with reduced glutathione [70-18-8], as the model low mol. thiol, showed that these compds. were reactive thiol-combining agents. The ability to react with SH groups is discussed in the light of the biol. activities of these naturally occurring a,b-unsatd. carbonyl compds. Structure-activity relations are discussed.