CAS No.121-45-9,Trimethyl phosphite Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	121-45-9
Name:	Trimethyl phosphite
Article Data:	66

Formula:	C₃H₉O₃P
Molecular Weight:	124.076
Synonyms:	Fosforyn trojmetylowy;Trimethoxyfosfin;Trimethyl phosphite;
EINECS:	204-471-5
Density:	1.052g/mLat 25°C(lit.)
Melting Point:	-78 °C
Boiling Point:	110.2 °C at 760 mmHg
Flash Point:	27.8 °C
Solubility:	Hydrolyzes with water.
Appearance:	clear colorless liquid
Hazard Symbols:	Xn
Risk Codes:	10-22-36/37/38
Safety:	26
Transport Information:	UN 2329 3/PG 3
PSA:	41.28000
LogP:	1.15250

Synthetic route

: 67-56-1
methanol

: 139111-73-2
tris(4-dimethylaminopyridine)phosphorus(3+) bromide

A: 84539-35-5
(3-bromopyridin-4-yl)-dimethyl-amine

B: 121-45-9
phosphorous acid trimethyl ester

Conditions

Conditions	Yield
Inert atmosphere;	A n/a B 100%

...Expand

: 67-56-1
methanol

: 51145-42-7
4',4'-dimethyl-2λ5-spiro[benzo[1,3,2]dioxaphosphole-2,2'-[1,3,2]oxazaphospholidin]-5'-one

A: 20570-25-6
2-methoxy-1,3,2-benzodioxaphosphole

B: 121-45-9
phosphorous acid trimethyl ester

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 0.5h; Ambient temperature;	A 85% B 5%

...Expand

: ammonium hexafluorophosphate

: 97688-35-2
(cyclopentadienyl)(iodomethyl)rhodium(P(OMe3)I

: 23936-60-9
1,2-bis(dimethylphosphanyl)ethane

A: 84330-26-7
(cyclopentadienyl)(I)rhodium(dpme)(PF6)

B: 121-45-9
phosphorous acid trimethyl ester

Conditions

Conditions	Yield
In benzene dropwise addn. of phosphine to Rh-compound in benzene (N2, Schlenk tube technique), stirring for 1h at room temp., filtn., washing with ether, drying in vac., dissolving in methanol, addn. of NH4PF6, stirring for 10 min; addn. of ether, filtn., washing with ether, recrystn. (acetone/ether);	A 83% B n/a

...Expand

: 67-56-1
methanol

: 121-45-9
phosphorous acid trimethyl ester

Conditions

Conditions	Yield
With potassium phosphate; tetrahexylammonium chloride; phosphorus trichloride In dichloromethane at 20℃; for 3h;	65%
With phosphorus trichloride Herstellung;
With pyridine; phosphorus trichloride

: mer-chloro(dinitrogen)(PPh3)(trimethylphosphite)3rhenium*0.166C6H6

: 7175-47-5
4-methylphenyl isocyanide

A: chloro(p-tolueneisocyanide)3(P(OMe)3)2rhenium

B: 603-35-0
triphenylphosphine

C: 121-45-9
phosphorous acid trimethyl ester

Conditions

Conditions	Yield
In tetrahydrofuran byproducts: N2; addn. of the isocyanide to the Re compd. in THF and stirring for 2 h at room temp.; filtn., concn. (vac.), addn. of CH2Cl2 or THF, then Et2O, filtn., washing with Et2O and drying in vac.;	A 50% B n/a C n/a

...Expand

: 67-56-1
methanol

: 7051-21-0
2-methoxy-2,3-dihydro-1,3,2-benzoxazaphosphole

A: 95-55-6
2-amino-phenol

B: 67528-50-1, 16841-91-1
2',3'-dihydro-3H-2λ5-[2,2']spirobi(benzo[1,3,2]oxazaphosphole)

C: 121-45-9
phosphorous acid trimethyl ester

Conditions

Conditions	Yield
	A 17% B 24% C 15%

...Expand

: 67-56-1
methanol

: 80948-53-4
N1-methyl-N1-(2,3:5,6-di-O-isopropylidene-α-D-mannofuranosylamido)-N2,N3-tetraethyldiamidophosphite

A: 80948-50-1, 80948-51-2
mixture of α- and β-2,3:5,6-di-O-isopropylidene-N-methyl-D-mannofuranosylamine

B: 121-45-9
phosphorous acid trimethyl ester

Conditions

Conditions	Yield
at 20℃; for 3h; Product distribution;

...Expand

: 67-56-1
methanol

: 90213-29-9
α-methyllyxo-D-furanoside 2,3,5-bicyclophosphite

A: 22416-73-5
methyl-α-D-lyxofuranoside

B: 121-45-9
phosphorous acid trimethyl ester

...Expand

: 67-56-1
methanol

: 1-N-methyl-3,5,6-tri-O-methyl-α-D-glucofuranosylamine 1,2-N,O-cyclodiethylphosphoramidite

A: 1-N-methyl-3,5,6-tri-O-methyl-α,β-D-glucofuranosylamine

B: 121-45-9
phosphorous acid trimethyl ester

...Expand

: 67-56-1
methanol

: 1-N-methyl-3,5,6-tri-O-methyl-α-D-glucofuranosylamine 1,2-N,O-cyclodiethylphosphoramidite

A: 1-N-methyl-3,5,6-tri-O-methyl-α,β-D-glucofuranosylamine

B: 121-45-9
phosphorous acid trimethyl ester

...Expand

Raw Materials

110-82-7

868-85-9

Downstream Products

115-10-6

152-18-1

593-53-3

19519-59-6

2216-69-5

66794-42-1

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Specification

The Trimethyl phosphite, with its CAS registry number 121-45-9, is a kind of clear colorless liquid with a strong foul odor. This chemical is sensitive to air and moisture. It can also be named as fosforyntrojmetylowy;Methyl phosphite ((MeO)3P); P(OCH3)3; Phosphonousacidtrimethylester; Trimethoxyfosfin. As to its usage, it is widely applied in many ways. It could be used as the organic phosphorus pesticide intermediates, such as for the dichlorvos, phosphorous amines and monocrotophos; And it could also be used as flame retardants of plastic and wood, as well as catalyst of synthetic polymer and additive of painting.

Physical properties about Trimethyl phosphite are: (1)ACD/LogP: -0.797; (2)ACD/LogD (pH 5.5): -0.80; (3)ACD/LogD (pH 7.4): -0.80; (4)ACD/BCF (pH 5.5): 1.00; (5)ACD/BCF (pH 7.4): 1.00; (6)ACD/KOC (pH 5.5): 8.78; (7)ACD/KOC (pH 7.4): 8.78; (8)#H bond acceptors:3; (9)#Freely Rotating Bonds: 3; (10)Flash Point: 27.778 °C; (11)Enthalpy of Vaporization: 33.446 kJ/mol; (12)Boiling Point: 110.229 °C at 760 mmHg; (13)Vapour Pressure: 28.1490001678467 mmHg at 25°C

Uses of Trimethyl phosphite: Trimethyl phosphite could react with chloro-triphenyl-methane to produce trityl-phosphonic acid dimethyl ester. This reaction could react in the temperature of 140 - 175 ℃.

When you are dealing with this chemical, you should be very careful. For being a kind of harmful chemical, it may cause damage to health. And it is irritating to eyes, respiratory system and skin and it will be very dangerous if swallowed. Therefore, if in case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: COP(OC)OC
(2)InChI: InChI=1S/C3H9O3P/c1-4-7(5-2)6-3/h1-3H3
(3)InChIKey: CYTQBVOFDCPGCX-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LC	inhalation	> 32700mg/m3/6 (32700mg/m3)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	National Technical Information Service. Vol. OTS0537047,
mouse	LCLo	inhalation	32700mg/m3/6H (32700mg/m3)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE	National Technical Information Service. Vol. OTS0537047,
mouse	LD50	intraperitoneal	4180mg/kg (4180mg/kg)		Environmental Research. Vol. 9, Pg. 1, 1975.
mouse	LD50	oral	4280mg/kg (4280mg/kg)	BEHAVIORAL: ATAXIA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	National Technical Information Service. Vol. OTS0540442,
rabbit	LD50	skin	2600mg/kg (2600mg/kg)		American Industrial Hygiene Association Journal. Vol. 34, Pg. 286, 1973.
rat	LCLo	inhalation	32700mg/m3/6H (32700mg/m3)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE	National Technical Information Service. Vol. OTS0537047,
rat	LD50	oral	1600mg/kg (1600mg/kg)		Albright & Wilson Inc. Vol. #OPB-3, Pg. 1984,