Detail of "1218-34-4"

CAS Number:
1218-34-4
Name:
L-Tryptophan,N-acetyl-
Superlist Name:
N-Acetyl-L-tryptophan
Molecular Structure:
Formula:
C₁₃H₁₄N₂O₃
Molecular Weight:
246.29
Synonyms:
Ac-Trp-OH;Ac-L-Trp-OH;Tryptophan,N-acetyl-, L- (8CI);(S)-N-Acetyltryptophan;Acetyl-L-tryptophan;Acetyltryptophan;L-N-Acetyltryptophan;N-Acetyltryptophan;NSC 90726;
EINECS:
214-935-9
Melting Point:
186 °C
Boiling Point:
586.6 °C at 760 mmHg
Flash Point:
308.6 °C
Appearance:
solid

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Reference

Amino acid solutions for parenteral administration: Amino acid solutions for parenteral administration. Aoki, Mitsuo; Watanabe, Kazuhiko; Murase, Shunichi; Naruto, Tokushima; Hiraoka, Isao (Otsuka Pharmaceutical Factory, Japan). Ger. Offen. DE 2614092 14 Oct 1976, 17 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: A61K037-18. PRIORITY: JP 75-40072 1 Apr 1975. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) During autoclaving of amino acid solns. contg. reducing sugars for parenteral administration, the Maillard reaction between their components is inhibited by substitution of N-acyl-L-tryptophan and N-acyl-L-proline for the free amino acids.Several substances with their cas registry numbers 5156-22-9 and 2752-38-7 may be metioned in this study. Thus, a soln. contg. 16 amino acids (0.06-3.60 g), N-acetyl-L-tryptophan [1218-34-4] 0.72 g, N-acetyl-L-proline (I) [68-95-1] 1.23 g, and glucose [50-99-7] 50.00 g in 1000 ml water was filtered, dispensed into 500 ml bottles, and autoclaved at 110.degree. for 60 min. .

Structure-function studies of N-acyl derivatives of tryptophan that function as specific cholecystokinin receptor antagonists: Structure-function studies of N-acyl derivatives of tryptophan that function as specific cholecystokinin receptor antagonists. Jensen, Robert T.; Jones, Susanna W.; Gardner, Jerry D. (Dig. Dis. Branch, Natl. Inst. Arthritis, Diabetes, Dig. Kidney Dis., Bethesda, MD 20205, USA). Biochim. Biophys. Acta, 761(3), 269-77 (English) 1983. CODEN: BBACAQ. ISSN: 0006-3002. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) L-Tryptophan [73-22-3], D-tryptophan [153-94-6] and each N-acyl deriv. tested inhibited cholecystokinin [9011-97-6]-stimulated amylase secretion and outflux of 45Ca by dispersed pancreatic acini, and there was a good correlation between the ability of a particular agent to inhibit the action of cholecystokinin on acinar function and its ability to inhibit binding of 125I-labeled cholecystokinin to pancreatic acini. The inhibition of the action of cholecystokinin caused by L-tryptophan and various acyl derivs. was specific, competitive, and fully reversible. In functioning as a cholecystokinin receptor antagonist, the relative potencies of the agents tested were: carbobenzoxy-L-tryptophan [7432-21-5] > benzotript [39544-74-6] > N-benzoyl-L-tryptophan [4302-66-3] = N-tert-butyloxycarbonyl-L-tryptophan [13139-14-5] > acetyl-L-tryptophan [1218-34-4] > L-tryptophan. In inhibiting the actions of cholecystokinin, native as well as N-acyl derivs. of D-tryptophan were euipotent with the corresponding compd. contg. L-tryptophan. L-Phenylalanine [63-91-2], L-methionine [63-68-3], or L-aspartic acid [56-84-8] did not alter the action of cholecystokinin on pancreatic acini. The antagonism of the actions of cholecystokinin was not restricted to N-acyl derivs. 2488-15-5 and 153-94-6 which are cas registry numbers of substances are two of reagents here. of L-tryptophan because N-tert-butyloxycarbonyl-L-methionine [2488-15-5] and N-tert-butyloxycarbonyl-L-phenylalanine [13734-34-4], but not N-tert-butyloxycarbonyl-L-aspartic acid [13726-67-5] also antagonized the actions of cholecystokinin. Both the nature of the N-acyl group and the amino acid residue appear to be important determinants of the affinity of the antagonist for the cholecystokinin receptor. For derivs. of L-tryptophan, the more hydrophobic the N-acyl moiety, the greater the affinity of the deriv. for the cholecystokinin receptor. .

Detail of "1218-34-4"

L-Tryptophan,N-acetyl-

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CAS No.1218-34-4 N-Acetyl-L-tryptophan

CAS No.1218-34-4 N-Acetyl-L-tryptophan

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CAS No.1218-34-4 N-Acetyl-L-tryptophan

CAS No.1218-34-4 N-Acetyl-L-tryptophan

CAS No.1218-34-4 N-Acetyl-L-tryptophan

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CAS No.1218-34-4 N-Acetyl-L-tryptophan

CAS No.1218-34-4 N-Acetyl-L-tryptophan

CAS No.1218-34-4 N-Acetyl-L-tryptophan

CAS No.1218-34-4 N-Acetyl-L-tryptophan

CAS No.1218-34-4 N-Acetyl-L-tryptophan

CAS No.1218-34-4 N-Acetyl-L-tryptophan

CAS No.1218-34-4 N-Acetyl-L-tryptophan

CAS No.1218-34-4 N-Acetyl-L-tryptophan

CAS No.1218-34-4 N-Acetyl-L-tryptophan

CAS No.1218-34-4 N-Acetyl-L-tryptophan

CAS No.1218-34-4 N-Acetyl-L-tryptophan

CAS No.1218-34-4 N-Acetyl-L-tryptophan

CAS No.1218-34-4 N-Acetyl-L-tryptophan

CAS No.1218-34-4 N-Acetyl-L-tryptophan

CAS No.1218-34-4 N-Acetyl-L-tryptophan

CAS No.1218-34-4 N-Acetyl-L-tryptophan

Reference