Detail of "12184-22-4"

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Molybdenocene-oligonucleotide binding study at physiological pH using NMR spectroscopy and cyclic voltammetry

All Rights Reserved. Molybdenocene-oligonucleotide binding study at physiological pH using NMR spectroscopy and cyclic voltammetry. Vera, Jose L.; Roman, Felix R.; Melendez, Enrique (Department of Chemistry, University of Puerto Rico, Mayagueez 00681, P. R.). Bioorganic & Medicinal Chemistry, 14(24), 8683-8691 (English) 2006 Elsevier Ltd. CODEN: BMECEP. ISSN: 0968-0896. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 6 The self-complementary oligonucleotide CGCATATATGCG was used as a model to establish the binding interactions of antitumor molybdenocene dichloride and DNA. The free dodecamer was first characterized using 1H, NOESY, and DQF-COSY NMR expts., which enable to pinpoint the guanines and adenines as well as the cytosines and thymines signals in the arom. region. Molybdenocene dichloride was characterized in saline and buffer solns. as function of pH by 1H NMR spectroscopy. In 10 mM NaCl/D2O soln. at pH of 6.5 and above, Cp2Mo(OD)(D2O)+ is in equil. with its dimeric species, [Cp2Mo(m-OH)2MoCp2]2+. In 25 mM Tris/4 mM NaCl/D2O at physiol. pH, a new stable species is formed, coordinated by the buffer, Tris(hydroxymethyl)aminomethane. The interactions of molybdenocene dichloride species with CGCATATATGCG were studied at different pH. At pH 6.5, in 4 mM NaCl/D2O soln., 1H NMR spectra of CGCATATATGCG exhibit downfield shifts in the signals assocd. mainly to adenines and guanines, upon addn. of molybdenocene dichloride. At pH 7.4, in 25 mM Tris/4 mM NaCl/D2O, molybdenocene species causes broadening and small downfield shifts to the purines and pyrimidine signals, suggesting that molybdenocene dichloride can get engaged in binding interactions with the oligonucleotide in a weak manner. 31P NMR spectra of these interactions at pH 7.4 showed no changes assocd.In this experiment, several chemicals are used like 918550-62-6 and 12184-22-4 to Mo(IV)-OP coordination, indicating that molybdenocene-oligonucleotide binding interactions are centered, most likely, on the bases. Cyclic voltammetry titrn. showed a 4.9% of molybdenocene-oligonucleotide interaction. This implicates that possible binding interactions with DNA are weak. .

Tribochemistry of cyclopentadienyl organometallic compounds

Tribochemistry of cyclopentadienyl organometallic compounds. Kadmiri, A.; Amaudrut, J.; Camelot, M.; Roques-Carmes, C.; Louis, F.; Mathia, T. (Ec. Natl. Super. Mec. Microtech., Besancon 25030, Fr.). ASLE Trans., 30(1), 111-20 (English) 1987. CODEN: ASLTA2. ISSN: 0569-8197. DOCUMENT TYPE: Journal CA Section: 51 (Fossil Fuels, Derivatives, and Related Products) Studies of the tribol. behavior of cyclopentadienyl organometallic complexes showed a decrease with test duration in the friction coeff., followed by a period of stability, and ending in a sharp increase. Complexes with Cl ligands were poor lubricants. Complexes with S ligands, particularly the Nb thio complexes, had good tribol. behavior. The lubricating properties of the S-contg. complexes depend on the electron d. 91152-22-6 and 12184-22-4 which are cas registry numbers of substances are two of reagents here. near the S atoms. Good tribol. behavior depended on the chem. stability of the compds. .