Detail of "122-48-5"

CAS Number:
122-48-5
Name:
2-Butanone,4-(4-hydroxy-3-methoxyphenyl)-
Superlist Name:
Vanillylacetone
Molecular Structure:
Formula:
C₁₁H₁₄O₃
Molecular Weight:
194.25
Synonyms:
Zingiberone;Zingerone;NSC 15335;Gingerone;4-Hydroxy-3-methoxybenzylacetone;4-(4-Hydroxy-3-methoxyphenyl)-2-butanone;3-Methoxy-4-hydroxybenzylacetone;(4-Hydroxy-3-methoxyphenyl)ethylmethyl ketone;
EINECS:
204-548-3
Density:
1.111 g/cm³
Melting Point:
40-41 °C(lit.)
Boiling Point:
323 °C at 760 mmHg
Flash Point:
123.7 °C
Risk Codes:
36/37/38
Safety:
26-36 Details

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The active part of the [6]-gingerol molecule in mutagenesis: The active part of the [6]-gingerol molecule in mutagenesis. Nakamura, Hakobu; Yamamoto, Takeshi (Fac. Sci., Konan Univ., Kobe 658, Japan). Mutat. Res., 122(2), 87-94 (English) 1983. CODEN: MUREAV. ISSN: 0027-5107. DOCUMENT TYPE: Journal CA Section: 17 (Food and Feed Chemistry) Section cross-reference(s): 4 The active part in mutagenesis of [6]-gingerol [23513-14-6], a mutagen in ginger (Zingiber officinale), was studied in Escherichia coli B/r. [6]-Shogaol [555-66-8] was isolated from the ginger by column chromatog. on silica gel. [6]-Shogaol was much less mutagenic (1 ′ 103 revertants/108 viable cells/700 mM) than [6]-gingerol (1 ′ 107 of the same units). 555-66-8 and 496-77-5 are cas registry numbers of chemicals which are used as reagents here. Mutation frequencies of their related compds. were 4 ′ 101 for zingerone [122-48-5], 1 ′ 107 for 3-hydroxymyristic acid [1961-72-4] and 3 ′ 102 for 12-hydroxystearic acid [106-14-9]. Curcumin, and myristic, stearic and oleic acids had no mutagenicity; and diacetone alc. [123-42-2] and butyroin [496-77-5] suppressed mutation. Thus, the active part of [6]-gingerol is the aliph. chain moiety contg. a OH group. .

The metabolism of zingerone, a pungent principle of ginger: The metabolism of zingerone, a pungent principle of ginger. Monge, Per; Scheline, Ronald; Solheim, Einar (Sch. Med., Univ. Bergen, Bergen, Norway). Xenobiotica, 6(7), 411-23 (English) 1976. CODEN: XENOBH.Several reagents such as 61152-62-3 is used here. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) Zingerone (I) [122-48-5] (100 mg/kg, i.p. or orally) was metabolized in rats and the glucuronide and sulfate conjugates appeared in the urine 24 hr after administration. Zingerone itself accounted for 50-5% and the corresponding carbinol accounted for 11-13% of the total detected in the urine. Side-chain oxidn. took place at all 3 available sites and oxidn. at the 3-position, giving rise to C6-C2 metabolites, predominated. Biliary excretion of zingerone (40% in 12 hr) occurred, and several O-demethylated metabolites found in the urine were of bacterial origin. .