CAS No.122-52-1,Triethyl phosphite Suppliers

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Basic Information

Molecular Structure:
CAS No.:	122-52-1
Name:	Triethyl phosphite
Article Data:	127

Formula:	C₆H₁₅O₃P
Molecular Weight:	166.157
Synonyms:	Ethylphosphite, (EtO)3P (7CI);Ethyl phosphite, Et3PO3 (4CI);NSC 5284;Triethoxyphosphine;Tris(ethoxy)phosphine;
EINECS:	204-552-5
Density:	0.989
Melting Point:	-112°C
Boiling Point:	159.8 °C at 760 mmHg
Flash Point:	54.1 °C
Solubility:	slightly soluble in water
Appearance:	clear colorless liquid
Hazard Symbols:	Xn
Risk Codes:	10-22-36/37/38-20/22
Safety:	16-26-36
Transport Information:	UN 2323 3/PG 3
PSA:	41.28000
LogP:	2.32280

Synthetic route

: 64-17-5
ethanol

: 122-52-1
triethyl phosphite

Conditions

Conditions	Yield
With ammonia; N,N-dimethyl-aniline; phosphorus trichloride In 1,2-dichloro-benzene at 10℃; pH=6 - 9; Temperature; pH-value;	99.71%
With triethanolamine; phosphorus trichloride In toluene at 15 - 50℃; for 2.7h; Reagent/catalyst;	96%
With Tri-n-octylamine; sodium carbonate; triethylamine; phosphorus trichloride In hexane at 5℃; for 2h; Temperature; Reagent/catalyst;	83.7%

: 109-83-1
(2-hydroxyethyl)(methyl)amine

: 589-57-1
diethyl phosphorylchloridite

A: 7077-42-1
2-ethoxy-3-methyl-1,3,2-oxazaphospholidine

B: 122-52-1
triethyl phosphite

Conditions

Conditions	Yield
at 10 - 15℃;	A 67% B 92%

...Expand

: 21646-99-1
diphosphorous acid tetraethyl ester

: 122-51-0
orthoformic acid triethyl ester

A: 65600-72-8
ethyl P-(diethoxymethyl)phosphonite

B: 122-52-1
triethyl phosphite

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate at 20℃; for 3h; argon atmosphere;	A 89% B 69%

...Expand

: 64-17-5
ethanol

: 96529-96-3
diethoxyphosphino ethyl cyclohexylphosphonate

A: 4546-15-0
ethyl hydrogen cyclohexylphosphonate

B: 122-52-1
triethyl phosphite

Conditions

Conditions	Yield
In benzene for 1h; Heating; argon atmosphere;	A 0.93 g B 87%

...Expand

: 64-17-5
ethanol

: 127088-86-2
S-(2-cyanoethyl) N,N,N',N'-tetraisopropylthiophosphorodiamidite

A: Thiophosphorous acid S-(2-cyano-ethyl) ester O,O'-diethyl ester

B: C11H23N2OPS

C: 122-52-1
triethyl phosphite

Conditions

Conditions	Yield
With 1H-tetrazole In acetonitrile at 25℃; for 0.166667h;	A 5% B 85% C 7%
With 1H-tetrazole In acetonitrile at 25℃; for 0.166667h;	A 22% B 18% C 60%

...Expand

: 589-57-1
diethyl phosphorylchloridite

: 7077-42-1
2-ethoxy-3-methyl-1,3,2-oxazaphospholidine

A: 22082-71-9
2-chloro-3-methyl-1,3,2-oxazaphospholidine

B: 122-52-1
triethyl phosphite

Conditions

Conditions	Yield
at 100℃; for 1h;	A 83% B 57%

...Expand

: 1498-42-6
phosphorodichloridous acid ethyl ester

: 64-17-5
ethanol

A: 589-57-1
diethyl phosphorylchloridite

B: 122-52-1
triethyl phosphite

Conditions

Conditions	Yield
With triethylamine In toluene	A 82% B 18%

...Expand

: 64-17-5
ethanol

: 79948-06-4
O,O-diethyl-N-butyl-N-isobutenyl aminophosphite

A: 6898-75-5
N-isobutylidenebutylamine

B: 122-52-1
triethyl phosphite

Conditions

Conditions	Yield
at 20℃; for 1440h;	A 72.5% B 81.7%

...Expand

: 79948-06-4
O,O-diethyl-N-butyl-N-isobutenyl aminophosphite

A: 6898-75-5
N-isobutylidenebutylamine

B: 122-52-1
triethyl phosphite

Conditions

Conditions	Yield
With ethanol at 20℃; for 1440h; further reagents;	A 72.5% B 81.7%

: 64-17-5
ethanol

: 73868-59-4
2-diethylamido-4-oxo-1,3-dimethyl-1,3,2-diazaphosphorinane

: 122-52-1
triethyl phosphite

Conditions

Conditions	Yield
at 70℃; for 3h;	81%

Raw Materials

97-93-8

64-17-5

Downstream Products

352-93-2

507-20-0

Total:75 Page 1 of 2 1 2 Next>>

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Specification

The Triethyl phosphite is an organic compound with the formula C₆H₁₅O₃P. The IUPAC name of this chemical is triethyl phosphite. With the CAS registry number 122-52-1, it is also named as Ethyl phosphite. The product's categories are Phosphonate Chemicals; Phosphite Ligands; Catalysis and Inorganic Chemistry; Phosphorus Compounds. Besides, it is a clear colorless liquid, which should be stored in cool and ventilated place.

The Triethyl phosphite is used as a plastic stabilizer and plasticizer, and also used as medicine, pesticide intermediates. It is used to produce analgesic pizotifen, viagra and other pesticides fenitrothion, and also used as plasticizers, stabilizers, lubricants and grease additives.

Physical properties about Triethyl phosphite are: (1)ACD/LogP: 0.67; (2)ACD/LogD (pH 5.5): 0.67; (3)ACD/LogD (pH 7.4): 0.67; (4)ACD/BCF (pH 5.5): 1.89; (5)ACD/BCF (pH 7.4): 1.89; (6)ACD/KOC (pH 5.5): 54.86; (7)ACD/KOC (pH 7.4): 54.86; (8)#H bond acceptors: 3; (9)#Freely Rotating Bonds: 6; (10)Polar Surface Area: 41.28 Å²; (11)Flash Point: 54.1 °C; (12)Enthalpy of Vaporization: 38.01 kJ/mol; (13)Boiling Point: 159.8 °C at 760 mmHg; (14)Vapour Pressure: 3.19 mmHg at 25°C.

Preparation: this chemical can be prepared by ethanol, phosphorus trichloride and ammonia. This reaction will need reagent Xylene.

When you are using this chemical, please be cautious about it as the following:
It is flammable and harmful by inhalation and if swallowed. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Besides, this chemical is irritating to eyes, respiratory system and skin. When you are using it, wear suitable protective clothing and keep away from sources of ignition - No smoking.

You can still convert the following datas into molecular structure:
(1)SMILES: O(P(OCC)OCC)CC
(2)InChI: InChI=1/C6H15O3P/c1-4-7-10(8-5-2)9-6-3/h4-6H2,1-3H3
(3)InChIKey: BDZBKCUKTQZUTL-UHFFFAOYAP
(4)Std. InChI: InChI=1S/C6H15O3P/c1-4-7-10(8-5-2)9-6-3/h4-6H2,1-3H3
(5)Std. InChIKey: BDZBKCUKTQZUTL-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LC50	inhalation	6203mg/m³/6H (6203mg/m³)	LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 218, 1992.
mouse	LD	intraperitoneal	> 500mg/kg (500mg/kg)		"Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 5, Pg. 286, 1953.
mouse	LD50	oral	3720mg/kg (3720mg/kg)	BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 218, 1992.
rabbit	LD50	skin	2800mg/kg (2800mg/kg)		Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 218, 1992.
rat	LC50	inhalation	11063mg/m³/6H (11063mg/m³)	LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 218, 1992.
rat	LD50	oral	1840mg/kg (1840mg/kg)	BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 218, 1992.