CAS No.1222-57-7,Imidazo[1,2-a]pyridine,2-[4-(methylsulfonyl)phenyl]- Suppliers

CAS Number:
1222-57-7
Name:
Imidazo[1,2-a]pyridine,2-[4-(methylsulfonyl)phenyl]-
Formula:
C14H12 N2 O2 S
Molecular Structure:
Synonyms:
Imidazo[1,2-a]pyridine,2-[p-(methylsulfonyl)phenyl]- (7CI,8CI); 2-(4-Methylsulfonylphenyl)imidazo[1,2-a]pyridine;2-(p-Methylsulfonylphenyl)imidazo[1,2-a]pyridine; Solimidin; Zolimidin;Zolimidine
Molecular Weight:
272.34
EINECS:
214-947-4
Density:
1.31 g/cm³
Boiling Point:
°Cat760mmHg
Flash Point:
°C
Safety:
Moderately toxic by ingestion and intraperitoneal routes. An anti-ulcer agent. When heated to decomposition it emits toxic fumes of SO_x and NO_x.Details

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Effect of some drugs on various types of experimental ulcers in rats: Effect of some drugs on various types of experimental ulcers in rats. Cattaneo, R.; D'Angelo, L.; Tonini, M.; Lecchini, S.; Gatti, G.; Teggia Droghi, M. (Ist. Farmacol. Med., Univ. Pavia, Pavia, Italy). Boll. Soc. Ital. Biol. Sper., 52(15), 1151-7 (Italian) 1976. CODEN: BSIBAC. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) 2-(P-methylsulfonylphenyl)imidazo[1,2-a]pyridine [1222-57-7] was more effective than Na 3-O-(carboxypropionyl)-11-oxo-18.beta.-olean-12-en-30-oate [63180-05-2] in inhibiting both indomethacin- and stress-induced gastric ulcers in rats, when the compds. were given orally at 100 mg/kg prior to the ulcerogenic stimulus. Parameters measured with the no. and extent of the lesions, and the 2 compds. differed quant. and sometimes qual. in their effects on these, e.g., the oleanoate compd. was unable to reduce the spread of the indomethacin-induced ulcers, although it decreased the frequency of their occurrence. Geranyl farnesyl acetate [51-77-4] and an unspecified polysulfate ester of an animal sialoglycopeptide were devoid of antiulcer activity in the situations studied.

Protective action of zolimidine against two different types of experimental intestinal ulcers: Protective action of zolimidine against two different types of experimental intestinal ulcers. Carminati, G. M. (Lab. Ric., Selvi e C. S.p.A., Milan, Italy). Farmaco, Ed. Prat., 33(2), 68-79 (Italian) 1978. CODEN: FRPPAO. ISSN: 0430-0912. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The incidence of intestinal ulcers caused by indomethacin (5 mg/kg/day for 8 days, rectally) in rats was reduced 84% by the simultaneous oral administration of zolimidine (I) [1222-57-7] at 200 mg/kg/day, and 93% by the same doses of I given i.p. Similarly, the incidence of intestinal ulcers caused by carrageenan (5% in the drinking water, for 40 days) in guinea pigs was reduced 86% by the simultaneous administration of 1% I in the diet. As in the stomach, I may stimulate mucus secretion by the intestinal musosal cells, rendering the intestinal wall more resistant to ulceration.

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