Detail of "122799-38-6"

Reference

Process for preparation of sulfur derivatives of 2'-fluoro-5-methyl-b-L-arabinofuranosyluridine

Process for preparation of sulfur derivatives of 2'-fluoro-5-methyl-b-L-arabinofuranosyluridine. Koo, Chang Hwi; Lee, Dong Hui; Mun, Jong Taek; Park, Gi Seok; Woo, Seong Ju (Bukwang Pharmaceutical Company Ltd., S. Korea). Repub. Korean Kongkae Taeho Kongbo KR 2003033819 A 1 May 2003, No pp. given (Korean). (Korea, Republic Of). CODEN: KRXXA7. CLASS: ICM: C07H019-06. APPLICATION: KR 2001-65967 25 Oct 2001. DOCUMENT TYPE: Patent CA Section: 33 (Carbohydrates) Sulfur derivs. of 2'-fluoro-5-methyl-b-L-arabinofuranosyluridine and a prepn. process thereof are provided, which compds. have antiviral activity, esp. anti-Hepatitis B virus(HBV) activity and less nerve toxicity. 122799-38-6 and 105281-19-4 which are cas registry numbers of chemicals are mentioned. The sulfur derivs. of 2'-fluoro-5-methyl-b-L-arabinofuranosyluridine include 1-(3-fluoro-hydroxy-5-mercaptomethyl-tetrahydro-furan-2-yl)-5-Me-1H-p yrimidine-2,4-dione represented by formula(1) and 1-(3-fluoro-hydroxy-5-(Me-oxomethylene-14-sulfanylmethyl) -tetrahydro-furan-2-yl)-5-Me-1H-pyrimidine-2,4-dione represented by formula 2. The process for prepg. the compd. of formula(2) comprises reacting L-FMAU compd. represented by formula(3) with trialkylphosphin, dialkylazodicarboxylate and thiolacetate in a solvent selected from THF, benzene, diethylether, dioxane, HMPT, pyridine and N,N-dimethylformamide at -10° to the room temp. .