Reference

Synthesis and Characterization of Poly(aluminosiloxane)-Bound (Ether-phosphine)ruthenium(II) Complexes

Synthesis and Characterization of Poly(aluminosiloxane)-Bound (Ether-phosphine)ruthenium(II) Complexes. Lindner, Ekkehard; Jaeger, Andreas; Kemmler, Martin; Auer, Friedrich; Wegner, Peter; Mayer, Hermann A.; Benez, Andreas; Plies, Erich ( Institut fuer Anorganische Chemie, Universitaet Tuebingen, Tuebingen D-72076, Germany). Inorganic Chemistry, 36(5), 862-866 (English) 1997 American Chemical Society. CODEN: INOCAJ. ISSN: 0020-1669. DOCUMENT TYPE: Journal CA Section: 67 (Catalysis, Reaction Kinetics, and Inorganic Reaction Mechanisms) Section cross-reference(s): 66 The trimethoxysilyl-(T)-functionalized ruthenium(II) complex cis-Cl(H)Ru(CO)(P~O)3 [2(T0)3] (P~O: P-coordinated ether-phosphine) is a sol-gel processed with tetraethoxysilane (TEOS, Q0) and aluminum 2-propanolate [Al(OiPr)3]. All components are simultaneously polycondensed to result in the poly(alumosiloxane)-bound ruthenium complexes A and B with various amts. of aluminum. From 31P and 13C CP MAS NMR as well as IR spectroscopy it can be concluded that the complex fragment cis-Cl(H)Ru(CO)(P~O)3 is preserved during the immobilization. Polymers A and B show a remarkable no. of Si-O-Al bonds in the 29Si solid state NMR spectra. The aluminum is incorporated as tetrahedrally coordinated AlO4 units with a formal neg. charge. The 6-fold coordinated AlO6 groups contg. water and hydroxide groups as ligands are sited as interstitials and act as their counterions. Stoichiometric formulas of A and B derived by 27Al and 29Si solid state NMR spectroscopy and energy dispersive X-ray spectroscopy (EDX) suggest that the amt. of aluminum can be adjusted by the applied stoichiometry. The two materials A and B act as hydrogenation catalysts of trans-crotylaldehyde and are easy to sep. from the reaction mixt. 78-10-4 and 123-73-9 are just another two chemicals used in this study. by simple centrifugation. .

Anti-inflammatory 17b-Thioalkyl-16a,17a-ketal and -acetal Androstanes: A New Class of Airway Selective Steroids for the Treatment of Asthma

Anti-inflammatory 17b-Thioalkyl-16a,17a-ketal and -acetal Androstanes: A New Class of Airway Selective Steroids for the Treatment of Asthma. Ashton, Michael J.; Lawrence, Christopher; Karlsson, Jan-Anders; Stuttle, Keith A. J.; Newton, Christopher G.; Vacher, Bernard Y. J.; Webber, Stephen; Withnall, Michael J. (Dagenham Research Centre, Rhone-Poulenc Rorer Central Research, Dagenham/Essex RM10 7XS, UK). Journal of Medicinal Chemistry, 39(25), 4888-4896 (English) 1996 American Chemical Society. CODEN: JMCMAR. ISSN: 0022-2623. DOCUMENT TYPE: Journal CA Section: 32 (Steroids) Section cross-reference(s): 1 The synthesis and anti-inflammatory potencies of a new class of 17b-thioalkyl-16a,17a-ketal and -acetal androstanes, e.g. I [R1 - R3 = Me, X = H, F; R1 = H, R2 = Pr, R3 = Me, X = H, F; R1 = X = H, R2 = Pr, R3 = Et, CHMe2; R1 = X = H, R2 = (E)-CH:CHMe, R3 = Me], are described. This new class of steroids was made by fragmentation of 2-thioxo-1,2-dihydropyrid-1-yl esters of the corresponding 17-acids to the 17-radical. The radical generated was trapped using a variety of radicophilic disulfides, giving a steroidal D-ring having acetal or ketal functionality at C-16 and C-17, together with a sulfide link at C-17. Compds. from this series bind to the glucocorticoid receptor with high potency and are functional agonists as measured by their ability to induce tyrosine aminotransferase activity in a rat hepatic cell line in vitro. These 17b-thioalkyl androstanes potently inhibit Sephadex-induced rat lung inflammation when administered directly into the airways. The high topical potency, together with a low propensity to induce systemic glucocorticoid-like side effects (rat thymus involution), provides the present compds. with a high degree of airway selectivity compared with currently available inhaled glucocorticoids. The presently described 17b-thioalkyl-16a,17a-ketal androstanes may be useful for therapies for inflammatory diseases such as asthma.Except for chemicals metioned above, 159344-73-7 and 123-73-9 are also used. .