Detail of "1232-80-0"

Reference

Changes in adrenal gland and thymus weight and adrenal corticosterone contents by sex steroid administration in newborn rats

Changes in adrenal gland and thymus weight and adrenal corticosterone contents by sex steroid administration in newborn rats. Itoh, Shinji; Hirota, Ryoji (Shionogi Res. Lab., Aburahi, Japan). Nippon Naibumpi Gakkai Zasshi, 53(2), 142-50 (Japanese) 1977. CODEN: NNGZAZ. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) Section cross-reference(s): 13 Newborn rats were given s.c. injections of steroid (0.5 mg.) at 18 postnatal h. Growth during the following 3 days was slightly suppressed by dehydroepiandrosterone (I) [53-43-0], 2-hydroxyestriol (II) [1232-80-0], or deoxyestrone (III) [53-45-2]. 57-83-0 and 50-22-6 are cas registry numbers of chemicals which are used as reagents here. The increase in thymus wt. was retarded by administration of testosterone [58-22-0], estradiol [50-28-2], estrone [53-16-7], estriol (IV) [50-27-1], 2-hydroxyestriol, 2-hydroxyestradiol [362-05-0], and I. Development of spleen was not influenced by the steroids testeed. The increment in adrenal gland wt. was delayed by I or progesterone [57-83-0], and accelerated by IV or diethylstilbestrol [56-53-1]. The adrenal content of corticosterone (V) [50-22-6] was increased markedly by IV, but decreased by cortisol [50-23-7] and this latter effect was prevented by simultaneous administration of IV. .

Novel and potent biological antioxidants on membrane phospholipid peroxidation: 2-hydroxy estrone and 2-hydroxy estradiol

Novel and potent biological antioxidants on membrane phospholipid peroxidation: 2-hydroxy estrone and 2-hydroxy estradiol. Nakano, Minoru; Sugioka, Katsuaki; Naito, Isao; Takekoshi, Susumu; Niki, Etsuo (Coll. Med. Care Technol., Gunma Univ., Maebashi 371, Japan). Biochem. Biophys. Res. Commun., 142(3), 919-24 (English) 1987. CODEN: BBRCA9. ISSN: 0006-291X. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Catechol estrogens, 2-hydroxyestrone [362-06-1], 2-hydroxyestradiol [362-05-0], and 2-hydroxyestriol [1232-80-0], were tested as possible antioxidants of phospholipid peroxidn. induced by Fe3+-ADP-adriamycin, using phospholipid liposomes as lipid source and a-tocopherol or other steroids as ref. compds. The parameters of antioxidant activities were: elongation of induction period, inhibition of O2 consumption required for lipid peroxidn.There are some commonly used reagents with their cas registry numbers 362-06-1 and 50-28-2 in this article., and inhibition of peroxidative cleavage of unsatd. phospholipid. Of the tested compds., 2-hydroxyestradiol or 2-hydroxyestrone had more potent activity than that of tocopherol. .