Detail of "12321-44-7"

Reference

The inhibition of gastrin production in the aged, following the administration of calcitonin

The inhibition of gastrin production in the aged, following the administration of calcitonin. Passeri, M.; Palummeri, E.; Soncini, G.; Monica, C.; Ferretti, P. G.; Galvagni, R. (Gerontol. Geriatr., Univ. degli Studi Parma, Parma, Italy). G. Clin. Med. (Bologna), 58(9-10), 321-38 (Italian) 1977. CODEN: GCMEAI. ISSN: 0017-0275. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) Section cross-reference(s): 13 The rise in serum gastrin [9002-76-0] concns. in elderly persons in response to a proein meal was inhibited by the infusion of porcine calcitonin [12321-44-7] or synthetic salmon calcitonin at 24 mg/kg and 20 mg, resp., doses which were too low to decrease serum Ca2+ concns. The antigastrin effect of calcitonin may be mediated by a decrease of Ca2+ in the cell cytosol. The postprandial regulation of calcemia is discussed.

Effects of porcine calcitonin on human platelet function

Effects of porcine calcitonin on human platelet function. Pogliani, E. M.; Corghi, E.; Ortolani, S.; Girardello, R.; Vigo, P. L.; Polli, I. E. (Univ. Milan, Milan, Italy). Biomed. Pharmacother., 38(2), 97-101 (English) 1984. CODEN: BIPHEX. ISSN: 0753-3322. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) The effects of different doses of porcine calcitonin (pCT) [12321-44-7] were tested in vitro and in vivo. In vitro, pCT at a concn. ranging 0.1-5 Medical Reserve Corps (M.R.C.) units/mL induced a dose-dependent inhibition of ADP [58-64-0] (1.2 mM) and collagen (2 mg/mL)-induced platelet aggregation, showing a prevalent action on the 2nd wave of ADP-induced aggregation and causing prolongation of the lag time and redn. of both max. aggregation and slope in collagen-induced aggregation. 45Ca uptake by platelets in the presence of the ionophore A 23187 and 14C-labeled serotonin [50-67-9] release were also inhibited in a dose-related fashion, using concns. ranging 1-10 M.R.C. units pCT. The in vivo tests, performed before and after a 7-day treatment with 2 different doses of pCT (1 and 160 M.R.C. units/daily, i.m.) confirmed the inhibitory effect of pCT on ADP- and collagen-induced platelet aggregation. The effect of 1 unit was stronger than that of 160 units. In vitro and in vivo effects of pCT on platelet functions probably depend on different mechanisms of action.