Detail of "1239-29-8"

Reference

Enhancement of fibrinolytic and thrombolytic potential in the rat by treatment with an anabolic steroid, furazabol

Enhancement of fibrinolytic and thrombolytic potential in the rat by treatment with an anabolic steroid, furazabol.Some chemicals with cas registry numbers like 57-88-5 and 9001-91-6 are also used. Kumada, Toshihiko; Abiko, Yasushi (Res. Inst., Daiichi Seiyaku Co., Ltd., Tokyo, Japan). Thromb. Haemostasis, 36(2), 451-64 (English) 1976. CODEN: THHADQ. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) During the oral administration of furazabol (I) [1239-29-8] to rats at the daily dose of 0.04, 0.2 or 1 mg/rat for 3 months, the most remarkable changes were increased plasminogen activator activity in blood and the lung tissue and decreased plasma fibronogen and cholesterol [57-88-5] levels. In most of the rats, the I treatment was effective in decreasing susceptibility to lactic acidosis-induced pulmonary thrombosis. No meaningful changes were obsd. in other parameters tested including ADP-induced platelet aggregability, plasma recalcification time, plasma plasminogen, plasma antiplasmin activity, plasminogen activator content of tissues other than the lungs and the release of vascular activator induced by venous occlusion. One month after cessation of I treatment, these altered parameters tended to return to normal. Independently of I treatment, a highly significant pos. correlation was found between the plasma activator activity and the pulmonary tissue activator content. I treatment may increase the circulating activator activity by enhancing activator content in the lungs. .

Excretion study of furazabol, an anabolic steroid, in human urine

Excretion study of furazabol, an anabolic steroid, in human urine. Kim, Taewook; Suh, Ja Won; Ryu, Jae-Chun; Chung, Bong Chul; Park, Jongsei (Doping Control Center, Korea Inst. Sci. Technol., Seoul 136-791, S. Korea). Journal of Chromatography, B: Biomedical Applications, 687(1), 79-83 (English) 1996 Elsevier. CODEN: JCBBEP. ISSN: 0378-4347.There are some reagents with their cas registry numbers 1239-29-8 and 148615-14-9 are used in this study. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Section cross-reference(s): 2 Furazabol and 16-hydroxyfurazabol represented the most abundant peaks in urinary metabolic profiles for two men obtained by gas chromatog.-mass spectrometry (GC-MS) after oral administration of 5 mg furazabol. The excreted amts. of unchanged furazabol were detd. and its response in GC-MS was compared with that of the 16-hydroxy metabolite. The max. excretion rates of these compds. were reacted 2-3 h after oral administration. The half-lives of unchanged furazabol for two human subjects, were 1.87 and 1.29 h resp. and the recovered amts. in 48 h was 24% (33% for one, 15% for the other). Also the spectrum of an unidentified metabolite is reported. .