Detail of "1239-45-8"

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CAS Number:
1239-45-8
Name:
Phenanthridinium,3,8-diamino-5-ethyl-6-phenyl-, bromide (1:1)
Superlist Name:
Ethidium bromide
Molecular Structure:
Formula:
C₂₁H₂₀BrN₃
Molecular Weight:
394.35
Deleted CAS:
131089-24-2,35322-47-5
Synonyms:
3,8-Diamino-5-ethyl-6-phenylphenanthridiniumbromide (6CI);Phenanthridinium, 3,8-diamino-5-ethyl-6-phenyl-, bromide(8CI,9CI);2,7-Diamino-10-ethyl-9-phenylphenanthridinium bromide;2,7-Diamino-9-phenyl-10-ethylphenanthridinium bromide;2,7-Diamino-9-phenylphenanthridine ethobromide;Dromilac;Homidium bromide;
EINECS:
214-984-6
Density:
g/cm³
Melting Point:
260-262 °C (dec.)(lit.)
Solubility:
40 g/L (25 °C) in water
Appearance:
Purple/maroon crystalline powder
Hazard Symbols:
T, T+
Risk Codes:
23-68-36/37/38-26-21/22-22
Safety:
36/37-45-36/37/39-28A-26-22-28 Details
Transport Information:
UN 2811 6.1/PG 1

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Reference

Determination of the mutagenic and genotoxic activities of the antibiotic distamycin A: Determination of the mutagenic and genotoxic activities of the antibiotic distamycin A. Mazza, G.; Mondello, C.; Nuzzo, F. (Dip. Genet. Microbiol., Univ. Pavia, Pavia, Italy). G. Ital. Chemioter., 30(1), 39-52 (Italian) 1983. CODEN: GICTAL. ISSN: 0017-0445. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 10 The mutagenic activity of distamycin A (I) [636-47-5] was studied in prokaryotic and lower eukaryotic genetic systems. In no case was genotoxic activity demonstrated. However, in the Salmonella test, distamycin A increased the mutagenic activity of ethidium bromide [1239-45-8]. The genotoxic activity of distamycin A was also studied in cultured mammalian cells by evaluating the effect on mitotic index, nuclear and chromosomal morphol., cell survival, and DNA synthesis, both replicative and repair. Distamycin A affected nuclear staining and the degree of condensation of the long arm of the Y chromosome without inducing chromosomal aberrations.In this experiment, several chemicals are used like 636-47-5 and 23214-92-8 An inhibitory effect on mitosis and cell survival was also obsd. However, DNA replication was not particularly affected, and unscheduled DNA synthesis was not induced by distamycin A. .

Effects of adriamycin on supercoiled DNA and calf thymus nucleosomes studied with fluorescent probes: Effects of adriamycin on supercoiled DNA and calf thymus nucleosomes studied with fluorescent probes. Simpkins, Henry; Pearlman, Leslie F.; Thompson, Leslie M. (California Coll. Med., Univ. California, Irvine, CA 92717, USA). Cancer Res., 44(2), 613-18 (English) 1984. CODEN: CNREA8. ISSN: 0008-5472. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The interaction of the antitumor drug adriamycin [23214-92-8] with nucleotides, polynucleotides, RNA, calf thymus nucleosomes, and DNA (including pBR322 supercoiled DNA) has been studied using the fluorescent probes terbium and N-pyrene maleimide. The lanthanide terbium is known to interact with guanine and xanthosine to produce high fluorescence enhancement. The nature of the interaction of the lanthanide with the heterocyclic ring in guanine [73-40-5] appears to involve both the C-2 and N-7 groups. A striking decrease in fluorescence enhancement was obsd. with all of the polynucleotides, RNA, DNA, and nucleosomes after treatment with adriamycin at molar ratios of 1:200 or less. It appears that adriamycin interacts with the guanine ring, displacing or preventing terbium access to its 2nd site of binding. However, with supercoiled DNA and nucleosomes, the displacement followed a destabilization of the helix at very low drug concns. The binding affinities of calf thymus DNA, pBR322 DNA, and calf thymus nucleosomes at 37° for adriamycin were of the same order of magnitude. Reaction with N-pyrene maleimide, which binds to histone H3, showed that adriamycin interacted with the nucleosome to increase the binding of the probe (only, however, at drug ratios far greater than those required to produce effects with DNA). No compositional changes of supercoiled or nucleosomal DNA or nucleosomal histones were obsd. by agarose gel or Na dodecyl sulfate:polyacrylamide gel electrophoresis, resp. The classic intercalating agent, ethidium bromide [1239-45-8], produced minimal displacement of the lanthanide from DNA, although an effect with RNA at high drug concns.Except for chemicals metioned above, 1239-45-8 and 523-98-8 are also used. was obsd. .

Detail of "1239-45-8"

Phenanthridinium,3,8-diamino-5-ethyl-6-phenyl-, bromide (1:1)

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Reference