Reference

Study of the effect of carbamine pesticides on the induction of liver enzymes of the rat and on the modification of microsomal phospholipids

Study of the effect of carbamine pesticides on the induction of liver enzymes of the rat and on the modification of microsomal phospholipids. Mountie, Jacques; Rivera, Freddy; Goudonnet, Herve; Escousse, Andre; Truchot, Roger Charles (Fac. Sci. Pharm. Biol., Univ. Dijon, Dijon, Fr.). Arch. Latinoam. Nutr., 33(3), 664-78 (French) 1983. CODEN: ALANBH. ISSN: 0004-0622. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The influence of maneb (I) [12427-38-2] and carbaryl [63-25-2] upon hepatic microsomal enzyme induction in the rat was studied. Both substances, when administered by themselves, only slightly affected liver wt., cytochrome P 450 [9035-51-2] rates and bilirubin glucuronosyltransferase [61969-98-0]. Carbaryl produced a slight induction, whereas I acts inversely. I, however, largely reversed the induction effects of phenobarbital when coadministered. 42613-26-3 and 61969-98-0 which are cas registry numbers of substances are two of reagents here. In simultaneously treated animals, the increase in the rate of hepatic microsomal cytochrome P 450 was lower than in the animals solely treated with phenobarbital. The distribution of unsatd. fatty acids into hepatic phosphatidylethanolamines was also largely reversed by I. .

The antifertility and antiadrenergic actions of thiocarbamate fungicides in laying hens

The antifertility and antiadrenergic actions of thiocarbamate fungicides in laying hens. Serio, R.; Long, R. A.; Taylor, J. E.; Tolman, R. L.; Weppelman, R. M.; Olson, G. (Merck Sharp and Dohme Res. Lab., Rahway, NJ 07065, USA). Toxicol. Appl. Pharmacol.Several reagents with their cas registry numbers 12427-38-2 and 137-26-8 are used here., 72(2), 333-42 (English) 1984. CODEN: TXAPA9. ISSN: 0041-008X. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The effects of thiram [137-26-8], ziram (I) [137-30-4], ferbam [14484-64-1], maneb [12427-38-2] and zineb [12122-67-7], on norepinephrine [51-41-2] synthesis by laying hens were investigated. Inhibition expts. with dopamine b-hydroxylase [9013-38-1] purified from chicken adrenals indicated that thiram, I, and ferbam are potent competitive inhibitors with the substrate ascorbate. Maneb and zineb were without effect at comparable concns. Expts. investigating the interaction of thiram, I, and ferbam with cupric ion suggested that these compds. probably inhibit the enzyme by complexing the fully oxidized Cu at its active site. Maneb and zineb also complexed cupric ions in soln. and thus their failure to inhibit is not due to their inability to complex Cu. When tested in vivo, thiram, I, and ferbam at oral doses of 32.5 mg/kg reduced the conversion of radioactive dopa given systemically, to brain norepinephrine. Since they did not affect the uptake of radioactive dopa by the brain or its subsequent decarboxylation within the brain to yield dopamine, these 3 compds. inhibit cerebral dopamine b-hydroxylase in vivo. In contrast maneb and zineb at an oral dose of 20 mg/kg had no significant effect on brain norepinephrine synthesis. Previously published results (Weppelman et al., 1980) demonstrated that thiram, I, and ferbam (but not maneb or zineb) have antifertility action in laying hens. The correlation between this action and inhibition of dopamine b-hydroxylase suggests that the antifertility effects of thiram, I, and ferbam might result from their antiadrenergic action. The observation that all doses of thiram in the diet which caused significant antigonadal action when fed to laying hens for 1 wk also significantly decreased central and peripheral stores of norepinephrine supports this conclusion. .