Detail of "124584-08-3"

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Potential Renal Protective Benefits of Intra-Operative BNP Infusion During Cardiac Transplantation

All Rights Reserved.Some chemicals with cas registry numbers like 124584-08-3 and 60-27-5 are also used. Potential Renal Protective Benefits of Intra-Operative BNP Infusion During Cardiac Transplantation. Zierer, A.; Voeller, R. K.; Melby, S. J.; Kawa, C. B.; Guthrie, T. J.; Baumgartner, M.; Pasque, M. K.; Moon, M. R.; Moazami, N. (Division of Cardiovascular Surgery, Washington University School of Medicine, Barnes Jewish Hospital, Saint Louis, MO, USA). Transplantation Proceedings, 38(10), 3680-3684 (English) 2006 Elsevier Inc. CODEN: TRPPA8. ISSN: 0041-1345. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Background: Recombinant BNP (nesiritide) is known to reduce endothelin levels, cause afferent arteriole vasodilation, and increase natriuresis and diuresis. We hypothesized that intraoperative infusion of BNP may benefit renal function in cardiac transplant patients. Methods: From June 2003 to Sept. 2005, 22 consecutive heart transplant patients received BNP at a dose of 0.01 mg/kg/min before initiation of cardiopulmonary bypass (group A). BNP infusion was continued for a mean of 3.3 ± 1.9 days. Hemodynamics, urine output, and serum creatinine levels were prospectively collected and compared with 22 consecutive patients who underwent heart transplantation between May 2002 and June 2003 following the identical transplant protocol, but without BNP infusion (group B). Results: At 24 h postoperatively, mean blood pressure was comparable between groups (87 ± 11 mm Hg vs 89 ± 17 mm Hg, P = .7), but pulmonary artery pressure (18 ± 5 mm Hg vs 24 ± 5 mm Hg, P = .001) and central venous pressure (12 ± 5 mm Hg vs 16 ± 4 mm Hg, P = .01) were lower with BNP infusion, whereas cardiac index was augmented (2.8 ± 0.5 vs 2.4 ± 0.6, P = .03). Requirement of low-dose inotropic and vasopressor support was equally distributed between groups (P 3 .72). Postoperative urine output for the initial 24 h was higher in group A (84 ± 15 vs 55 ± 36 mL/h, P = .01). None of the patients with BNP infusion required addnl. diuretics or renal replacement therapy during the first week after transplantation. Mean postoperative serum creatinine levels as compared with preoperative values remained unchanged within group A (P = .12), but increased significantly in group B (P < .001). Conclusions: Intraoperative BNP infusion in heart transplant recipients was assocd. with favorable postoperative hemodynamics, significantly improved urine output, and stable serum creatinine levels. A prospective, randomized, multicenter trial is warranted to evaluate the potential renal protective benefits of intraoperative BNP infusion in this patient population. .

Human brain natriuretic peptide-like immunoreactivity in human brain

Human brain natriuretic peptide-like immunoreactivity in human brain. Takahashi, Kazuhiro; Totsune, Kazuhito; Sone, Masahiko; Ohneda, Makoto; Murakami, Osamu; Itoi, Keiichi; Mouri, Toraichi (Sch. Med., Tohoku Univ., Miyagi 980, Japan). Peptides (Fayetteville, N. Y.), 13(1), 121-3 (English) 1992. CODEN: PPTDD5.Some commonly used reagents like 124584-08-3 is used in this experiment. ISSN: 0196-9781. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) The presence of immunoreactive human brain natriuretic peptide in the human brain was studied with a specific RIA for human brain natriuretic peptide-32. This assay showed no significant cross-reaction with human alpha atrial natriuretic peptide, porcine brain natriuretic peptide or rat brain natriuretic peptide. Immunoreactive human brain natriuretic peptide was found in all 5 regions of human brain examd. (cerebral cortex, thalamus, cerebellum, pons, and hypothalamus)(0.6-6.7 pmol/g wet wt.). These values were comparable with the concns. of immunoreactive alpha atrial natriuretic peptide in human brain (0.5-10.1 pmol/g wet wt.). However, Sephadex G-50 column chromatog. showed that the immunoreactive human brain natriuretic peptide in the human brain eluted earlier than synthetic human brain natriuretic peptide-32. Evidently, human brain natriuretic peptide is present in the human brain mainly as larger mol. wt. forms. .