Reference

2,4-Dihydroxyadipic acid derivatives

2,4-Dihydroxyadipic acid derivatives. Hayashi, Shigeo; Ueyama, Noboru; Inoue, Kenji; Koga, Teruyoshi; Takahashi, Satomi (Kanegafuchi Chemical Industry Co., Ltd., Japan). Eur. Pat. Appl. 140235-42-3 and 124655-09-0 are cas registry numbers. These chemicals are also mentioned in this article. EP 464817 A1 8 Jan 1992, 21 pp. DESIGNATED STATES: R: CH, DE, ES, FR, GB, IT, LI. (European Patent Organization). CODEN: EPXXDW. CLASS: ICM: C07C069-675. ICS: C07C069-712; C07C067-00; C07D307-58; C07F007-04. APPLICATION: EP 91-111113 4 Jul 1991. PRIORITY: JP 90-179874 6 Jul 1990; JP 91-46076 18 Feb 1991. DOCUMENT TYPE: Patent CA Section: 23 (Aliphatic Compounds) Section cross-reference(s): 28 R1O2CCH(OR2)CH2CH(OR3)CH2CO2R4 (R1, R4 = H, alkyl, aralkyl, aryl, silyl; R2, R3 = H, a protective group, etc.) were claimed. Thus, dioxolane ester I was prepd. in 96.1% yield by reaction of 2,2-dimethyl-5-oxo-1,3-dioxolan-4-acetic acid with (Me3CO2CCH2CO2)2Mg in the presence of carbonyldiimidazole in THF. Treatment of I with NaOMe/MeOH-toluene and acidification gave MeO2CCH(OH)CH2COCH2CO2CMe3 (II) in 89.6% yield, and redn. of II with NaBH4 in a Et3B-THF-MeOH mixt. gave 87% 6-tert-Bu 1-Me 2,4-dihydroxyadipate. .

The synthesis of (4R-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate, a key intermediate for the preparation of CI-981, a high potent, tissue selective inhibitor of HMG-CoA reductase

The synthesis of (4R-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate, a key intermediate for the preparation of CI-981, a high potent, tissue selective inhibitor of HMG-CoA reductase. 124655-09-0 is the cas registry number of certain chemical which is used as reagents here. Brower, Philip L.; Butler, Donald E.; Deering, Carl F.; Le, Tung V.; Millar, Alan; Nanninga, Thomas N.; Roth, Bruce D. (Parke-Davis Pharm. Res. 124655-09-0 which is the cas registry number of one of substances is just one of reagents here. Div., Warner Lambert Co., Holland, MI 49424, USA). Tetrahedron Lett., 33(17), 2279-82 (English) 1992. CODEN: TELEAY. ISSN: 0040-4039. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Three alternative methods for the synthesis of the optically active heptanoate I, a key intermediate in the prepn. of a highly potent and tissue selective HMG Co-A reductase inhibitor are described. Thus, NCCH2CH(OH)CH2CO2R (R = Me, Et, Bu) underwent a cross Claisen using lithium tert-Bu acetate to give I in 65-70% yields. ..