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| CAS No.: | 125-29-1 |
|---|---|
| Name: | HYDROCODONE |
| Article Data: | 55 |
| Molecular Structure: | |
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| Formula: | C18H21NO3 |
| Molecular Weight: | 299.37 |
| Synonyms: | 4aH-8, 9c-Iminoethanophenanthro[4,5-bcd]furan-5-(6H)-one, 7,7a,8, 9-tetrahydro-3-methoxy-12-methyl-;Codinovo;Morphinan-6-one,4,5-epoxy-3-methoxy-17- methyl-,(5R)-;Hydrocodon;Hydrocone;Dihydrocodeinone;Hydrocodone;Multacodin;Codeinone, dihydro-;6-Oxo-3-methoxy-N-methyl-4, 5-epoxymorphinan;DICO;Bekadid;Morphinan-6-one, 4,5.alpha.-epoxy-3-methoxy-17-methyl-;Dicodid;Morphinan-6-one, 4,5-epoxy-3-methoxy-17-methyl-, (5.alpha.)-;4, 5.alpha.-Epoxy-3-methoxy-17-methylmorphinan-6-one;Hilafilcon B;DIHYDROCODEIN-ONE;4,5α-EPOXY-3-METHOXY-17-METHYLMORPHINAN-6-ONE; |
| EINECS: | 204-733-9 |
| Density: | 1.31 g/cm3 |
| Melting Point: | 194-197°C |
| Boiling Point: | 461.4 °C at 760 mmHg |
| Flash Point: | 232.9 °C |
| Solubility: | Soluble in alcohol; insoluble in water. |
| Appearance: | White to pale yellow crystals |
| Hazard Symbols: | F,T |
| Risk Codes: | 11-23/24/25-39/23/24/25 |
| Safety: | Poison by intravenous and subcutaneous routes. When heated to decomposition it emits toxic fumes of NOx. |
| PSA: | 38.77000 |
| LogP: | 1.87120 |
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Chemistry
Molecular Formula: C18H21NO3
Molar mass: 299.3642 g/mol
EINECS: 204-733-9
Density: 1.31 g/cm3
Flash Point: 232.9 °C
Index of Refraction: 1.633
Boiling Point: 461.4 °C at 760 mmHg
Vapour Pressure: 1.07E-08 mmHg at 25°C
Structure of Hydrocodone (CAS NO.125-29-1):
XLogP3-AA: 2.2
H-Bond Donor: 0
H-Bond Acceptor: 4
SMILES: O=C4[C@@H]5Oc1c2c(ccc1OC)C[C@H]3N(CC[C@]25[C@H]3CC4)C
InChI: InChI=1/C18H21NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3,6,11-12,17H,4-5,7-9H2,1-2H3/t11-,12+,17-,18-/m0/s1
InChIKey: LLPOLZWFYMWNKH-CMKMFDCUBC
Std. InChI: InChI=1S/C18H21NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3,6,11-12,17H,4-5,7-9H2,1-2H3/t11-,12+,17-,18-/m0/s1
Std. InChIKey: LLPOLZWFYMWNKH-CMKMFDCUSA-N
History
Hydrocodone (CAS NO.125-29-1) was first synthesized in Germany in 1920.It was approved by the Food and Drug Administration on 23 March 1943 for sale in the United States and Canada under the brand name Hycodan . The particular niche in which Hydrocodone is most commonly used is a problem. For the latter indication, at the 5 to 10 mg dose range hydrocodone is more powerful than most cough suppressants, being roughly equal to its derivative dihydrocodeinone enol acetate, with the top of the list being Morphine and Hydromorphone (Dilaudid cough syrup) and Methadone (methadone linctus, about 33 percent the concentration of the liquid used for opioid physical dependence maintenance or detoxification) and dihydrocodeine being right below.
Uses
Hydrocodone (CAS NO.125-29-1) is an orally active narcotic analgesic (pain reliever) and antitussive (cough suppressant). It is most commonly used is as an intermediate strength centrally acting analgesic and strong cough suppressant, especially in those for whom histamine release and attendant itching from codein, and is often compounded with other analgesics like paracetamol or ibuprofen.
Production
Hydrocodone (CAS NO.125-29-1) is a semi-synthetic opioid derived from two of the naturally occurring opiates, codeine and thebaine.
Toxicity Data With Reference
| 1. | scu-rat LD50:150 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 3 (1953),238. | ||
| 2. | scu-mus LD50:86 mg/kg | JPETAB Journal of Pharmacology and Experimental Therapeutics. 52 (1934),468. | ||
| 3. | ivn-cat LDLo:9 mg/kg | AEPPAE Naunyn-Schmiedebergs Archiv fuer Experimentelle Pathologie und Pharmakologie. 194 (1940),296. | ||
| 4. | ivn-rbt LDLo:7 mg/kg | AEPPAE Naunyn-Schmiedebergs Archiv fuer Experimentelle Pathologie und Pharmakologie. 194 (1940),296. |
Safety Profile
Poison by intravenous and subcutaneous routes. When heated to decomposition it emits toxic fumes of NOx.
RIDADR: 1544
HazardClass: 6.1(b)
PackingGroup: III
Specification
Hydrocodone (CAS NO.125-29-1) also can be called Dicodid ; Dihydrocodeinone ; Morphinan-6-one, 4,5.alpha.-epoxy-3-methoxy-17-methyl- ; Hydrocodon ; Codinovo ; Hydrocodone anhydrous ;and ; (5alpha)-3-Methoxy-17-methyl-4,5-epoxymorphinan-6-one .