Detail of "125-40-6"

Reference

Routine therapeutic drug monitoring using the Perkin-Elmer Mark II gas chromatograph fitted with a nitrogen-selective detector

Routine therapeutic drug monitoring using the Perkin-Elmer Mark II gas chromatograph fitted with a nitrogen-selective detector. Menyharth, Paul; Levy, Arthur L.; Lehane, Derek P. (Clin. Chem. Lab., Saint Vincent's Hosp. Med. Cent., New York, N. Y., USA). Chromatogr. Newsl., 4(2), 15-19 (English) 1976. CODEN: CHNLAZ. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) A gas-chromatog. procedure utilizing a N-selective detector is described for the rapid quantitation of serum levels of allo- [52-43-7], amo- [57-43-2], buta- [125-40-6], hepta- [509-86-4], pento- [76-74-4], pheno- [50-06-6] and secobarbital [76-73-3], plus the anticonvulsants, phenytoin [57-41-0] and primidone [125-33-7]. Extn. of acidified serum into org. solvents contg. internal stds. was followed by on-column methylation with methanolic trimethylphenyl ammonium hydroxide. The drugs were sepd. on a column of 3% OV-101 on Gas-Chrom Q, 100-120 mesh, by temperature programming from 150.degree. to 290.degree.. Calibration curves were linear through the toxic ranges of the drugs, and recovery from serum averaged 98%. The day-to-day coeff. of variation at therapeutic and toxic levels were: phenobarbital-6%, phenytoin-6%, and primidone-7%, while within-run precision for each drug was <4%.

Solubility for normal and branched chain alkyl barbiturates in water

Solubility for normal and branched chain alkyl barbiturates in water. II. Relation with apparent molar volume. Laprade, B.; Mauger, J. W.; Petersen, H., Jr.; Lausier, J. M.; Paruta, A. N. (Abbott Lab., North Chicago, Ill., USA). Drug. Dev. Ind. Pharm., 3(1), 73-85 (English) 1977. CODEN: DDIPD8. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) The H2O soly. of C5 straight-chain alkyl barbiturates decreased linearly as the alkyl chain length, and thus the molar vol., increased. This relation was also true among a series of C5 branced-chain alkyl barbiturates. For both straight-and branched chain alkyl barbiturates, the soly. decreased linearly with a slope of .apprx.3 mg/C atom and the molar vol. increased linearly with a slope of .apprx.16.6 mL/C atom as the no. of catoms increased. The molar vols. 57-43-2 and 33376-25-9 are also in the experiment. of 5-ethyl-5-(1-methylpropyl)barbituric acid [125-40-6] and 5-ethyl-5-(2-methylpropyl)barbituric acid [1135-61-1] and of 5-ethyl-5-(1-methylbutyl)barbituric acid [76-74-4] and 5-ethyl-5-(3-methylbutyl)barbituric acid [57-43-2] were the same, and the solys. of these pairs were also about the same. However, the branched compds. were less sol. than the straight-chain compds. of similar molar vol. The m.p.s. were not related to the aq. soly. trends or the apparent molar vol. relation. A rank order correlation was obsd. between the energy of vaporization and the solys. of both the linear and branched chain series. .