Reference

Screening for new compounds with antiherpes activity

Screening for new compounds with antiherpes activity. Alarcon, Balbino; Lacal, Juan Carlos; Fernandez-Sousa, Jose Maria; Carrasco, Luis (Cent. Biol. Mol., Univ. Auton., Madrid, Spain). Antiviral Res., 4(5), 231-44 (English) 1984. CODEN: ARSRDR. ISSN: 0166-3542. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 2, 15, 18 A no. of compds. have been tested for antiherpes activity. Actinobolin [24397-89-5], amicetin [17650-86-1], carrageenan [9000-07-1], laspartomycin [12676-61-8], megalomicin C [49669-76-3], pleuromutilin [125-65-5], suramin [145-63-1], and tetracenomycin C [71135-22-3] showed significant protection of HeLa cell monolayers infected with herpes simplex virus type 1. The action of these new antiherpes compds. was compared with those antiherpes agents that have been described previously. Actinobolin, amicetin and tetracenomycin C were also active against viruses other than herpes simplex.

Pleuormutilin solvates

Pleuormutilin solvates. Knauseder, Franz; Wagner, Helmut (Biochemie, Austria). U.S. US 4089891 16 May 1978, 3 pp. (English). (United States of America). CODEN: USXXAM. CLASS: IC: C07C069-67. NCL: 560188000. PRIORITY: CH 75-9623 23 Jul 1975. DOCUMENT TYPE: Patent CA Section: 16 (Fermentations) Solvates of pleuromutilin (I) [125-65-5] with halogenated aliph. hydrocarbons, esp. alkanes, are prepd. to purify I from crude fermn. broths by a process that involves: formation of I-solvents, isolation of I-solvate, and conversion of the I-solvate to I. A process also is discussed for the prepn. of 14-deoxy-14-[2-(diethylaminoethyl)mercaptoacetoxy] mutilin (II) [56142-71-3]. Thus, 25.3 g crude I (78%) was dissolved in 250 mL 1,1,1-trichloroethane (III) [71-55-6] and filtered. After 24 h at 2°, the crystd. I-III solvate was filtered, washed with cold III, and dried to yield 25.8 g solvate contg. 70.8% I (yield 92.7%). After 24 h at 60°, 18.3 g I (94.5%) was obtained from 24.5 g solvate.