Reference

Determination of dextrorphan in plasma and evaluation of bioavailability of dextromethorphan hydrobromide in humans

Determination of dextrorphan in plasma and evaluation of bioavailability of dextromethorphan hydrobromide in humans. Ramachander, Gollamudi; Williams, Florence D.; Emele, Jane Frances (Warner-Lambert Res. Inst., Morris Plains, N. J., USA). J. Pharm. Sci., 66(7), 1047-8 (English) 1977. CODEN: JPMSAE. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) A fluorescence method is described for the estn. of dextrorphan (I) [125-73-5], a metabolite of dextromethorphan, in plasma. The bioavailability of dextromethorphan-HBr [125-69-9] after 30 mg orally, as measured by the concn. of total (free and conjugated) I in the plasma, was detd. in 6 human volunteers with this procedure.

Liquid chromatographic analysis of pharmaceutical syrups using pre-columns and salt-adsorption on Amberlite XAD-2

Liquid chromatographic analysis of pharmaceutical syrups using pre-columns and salt-adsorption on Amberlite XAD-2. Mohammed, Hussain Y.; Cantwell, Frederick F. (Dep. Chem., Univ. Alberta, Edmonton, Alberta, Can.). Anal. Chem., 50(3), 491-6 (English) 1978. CODEN: ANCHAM. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Twenty-nine drug compds. are chromatographed in acidic, neutral, and alk. solns. contg. varying amts. of water and methanol on a column of Amberlite XAD-2 nonionic resin. Cationic conjugate acids of amine drugs are adsorbed via "salt-adsorption". Their retention vols. depend on concn. and type of anion (e.g. Cl-, ClO4-) added to the mobile phase as well as on its pH and solvent compn. Pharmaceutical sirups can be analyzed without prior treatment when short pre-columns contg. anion-exchange resin and XAD-2 are added. As examples, synthetic and com. sirups are analyzed for phenylephrine-HCl [61-76-7], acetaminophen [103-90-2], glyceryl guaiacolate [93-14-1], and dextromethorphan-HBr [125-69-9].