Detail of "125-84-8"

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CAS Number:
125-84-8
Name:
2,6-Piperidinedione,3-(4-aminophenyl)-3-ethyl-
Superlist Name:
Aminoglutethimide
Molecular Structure:
Formula:
C₁₃H₁₆N₂O₂
Molecular Weight:
232.31
Synonyms:
Glutarimide,2-(p-aminophenyl)-2-ethyl- (6CI,7CI,8CI);(RS)-Aminoglutethimide;3-(4-Aminophenyl)-3-ethylpiperidine-2,6-dione;Ba-16038;Cytadren;DL-Aminoglutethimide;Elipten;NSC 330915;Orimeten;p-Aminoglutethimide;
EINECS:
204-756-4
Density:
1.173 g/cm³
Melting Point:
152-154 °C(lit.)
Boiling Point:
457.4 °C at 760 mmHg
Flash Point:
230.4 °C
Solubility:
slightly soluble in water
Appearance:
white solid
Hazard Symbols:
Xi
Risk Codes:
36/37/38
Safety:
26-36 Details
Transport Information:
UN 3249

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Pharmacological mechanisms of estrogen suppression with aminoglutethimide in women with breast cancer: Pharmacological mechanisms of estrogen suppression with aminoglutethimide in women with breast cancer. Santen, R. J.; Lipton, A.; Harvey, H.; Boucher, A. E.; Henderson, C. (Div. Endocrinol., Milton S. Hershey Med. Cent., Hershey, PA, USA). Aminoglutethimide Aromatase Inhib. Treat. Cancer, Int. Symp., Meeting Date 1983, 38-57. Edited by: Nagel, Gerhard A.; Santen, Richard J. Huber: Bern, Switz. (English) 1984. CODEN: 53SRAN. DOCUMENT TYPE: Conference; General Review CA Section: 1 (Pharmacology) Section cross-reference(s): 2 A review, with 19 refs., of the mechanisms of estrogen suppression by aminoglutethimide (I) [125-84-8] in the treatment of hormone-dependent breast carcinoma in women. New data which indicates that low doses of I (500 mg, daily) in combination with hydrocortisone [50-23-7] blocked estrogen formation to the same extent as that achieved by the more std. dose (1 g, daily) is also discussed.

Effects of aminoglutethimide and tolbutamide on the metabolism of radiolabeled C19 steroids by piglet testis microsomes: Effects of aminoglutethimide and tolbutamide on the metabolism of radiolabeled C19 steroids by piglet testis microsomes. Lyne, Cynthia; Gower, D. B. (Med. Sch., Guy's Hosp., London SE1 9RT, UK). Biochem. Soc. Trans., 13(6), 1124-5 (English) 1985. CODEN: BCSTB5. ISSN: 0300-5127. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) In fresh rat testis microsomes, aminoglutethimide (I) [125-84-8] completely inhibited cytochrome P 450 [9035-51-2]-dependent aromatization and hydroxylation of testosterone [58-22-0] or 19-hydroxy-4-androstene-3,17-dione [510-64-5]. In microsomes that were stored for 9 mo, 4-ene-5a-reductase [9081-34-9] activity was inhibited by I and19-hydroxy-4-androstenedione formation was completely abolished. Tolbutamide (II) [64-77-7] at low doses only slightly inhibited estrone [53-16-7] formation from testosterone, but 150 mg II markedly suppressed the formation of 7- and 16-hydroxylated metabolites. In stored microsomes, II dose-dependently inhibited 17b-hydroxysteroid dehydrogenase [9015-81-0] activity. With 19-hydroxy-4-androstendione as the substrate, II caused little change in estrone formation. Thus, II, like I, appears to affect steroid metab. in parallel to the effect of these antidiabetics on thyroid function.