Detail of "1253-28-7"

CAS Number:
1253-28-7
Name:
19-Norpregn-4-ene-3,20-dione,17-[(1-oxohexyl)oxy]-
Superlist Name:
Gestonorone caproate
Molecular Structure:
Formula:
C26H38 O4
Molecular Weight:
414.64
Synonyms:
19-Norpregn-4-ene-3,20-dione,17-hydroxy-, hexanoate (6CI,7CI,8CI); Hexanoic acid, ester with17-hydroxy-19-norpregn-4-ene-3,20-dione (8CI);17-Hydroxy-19-norpregn-4-ene-3,20-dione hexanoate; 17a-Hydroxy-19-norprogesteronecaproate; 17a-Hydroxy-19-norprogesteronecapronate; 17b-Acetyl-17-hydroxyestr-4-ene-3-onehexanoate; 19-Nor-17a-caproyloxy-4-pregnene-3,20-dione; 19-Norpregn-4-ene-3,20-dione17-caproate; Depostat; Gestonorone caproate; Gestonorone capronate; Gestronolcaproate; Gestronol hexanoate; NSC 84054; Primostat; SH 582; SH 80582; ZK 5623
Density:
1.11g/cm³
Boiling Point:
535.4°Cat760mmHg
Flash Point:
228.4°C
Safety:
Poison by intramuscular route. Experimental reproductive effects. A steroid. When heated to decomposition it emits acrid smoke and irritating fumes. Details

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Toxicity study of gestonorone caproate: Toxicity study of gestonorone caproate. 1. Acute toxicity study in rat and mouse. Ezumi, Kichizo; Nakao, Hisao; Horikawa, Tetsuo (Nihon Schering K. K. Lab., Osaka, Japan). Iyakuhin Kenkyu, 8(3), 296-301 (Japanese) 1977. CODEN: IYKEDH. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) Acute toxicity of gestonorone caproate (I) [1253-28-7] was investigated with respect to 4 routes (orally, s.c., i.p., i.m.) of administration in rats and with respect to routes (orally, s.c., i.p.) in mice. The median lethel doses obtained for i.p. administration in rats were 6,800 mg/kg in male and 8,200 mg/kg in female, but those for the other administrations were more than technically applicable maximum doses; 400 mg/kg for i.m. and 10,000 mg/kg for others. A decrease in motility was obsd. in most of the animals. The edema and partial hemorrhage of the lung were obsd. in rats. The swelling of liver and/or spleen was found in mice given I orally or i.p.

The nuclear uptake of androgen by human benign prostate in vitro: action of antiandrogens: The nuclear uptake of androgen by human benign prostate in vitro: action of antiandrogens. Symes, Elizabeth K.; Milroy, E. J. G.; Mainwaring, W. I. P. (Androgen Physiol. Dep., Imperial Cancer Res. Fund, London, Engl.). J. Urol., 120(2), 180-3 (English) 1978. CODEN: JOURAA. ISSN: 0022-5347. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) An in vitro test system suitable to assess the potency of putative antiandrogens was developed, using human benign prostatic tissue. Slices of tissue were incubated in the presence of 3H-labeled testosterone (I) [58-22-0] and the uptake into nuclei was detd. The nature of the nuclear radioactivity and the steroid specificity indicated a mechanism similar to that established in the rat ventral prostate. At 1000-10,000-fold excess, cyproterone acetate [427-51-0] and hydroxylated flutamide competed extensively with I for nuclear uptake, whereas flutamide [13311-84-7] and gestonorone capronate [1253-28-7] competed only 20% even at the highest concn. and diethylstilbestrol [56-53-1] did not compete with I at any concn.