Detail of "125580-28-1"

Reference

Physiological role of neuropeptide Y in the regulation of the ascending phase of the peristaltic reflex

Physiological role of neuropeptide Y in the regulation of the ascending phase of the peristaltic reflex. Grider, John R.; Langdon, Lea E. (Department of Physiology and Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA). American Journal of Physiology, 285(6, Pt. 1), G1139-G1146 (English) 2003 American Physiological Society. CODEN: AJPHAP. ISSN: 0002-9513. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) The physiol. role of neuropeptide Y (NPY) and of specific NPY receptors in regulating the intestinal peristaltic reflex was examd. in three-compartment flat-sheet prepns. of rat colon. Graded muscle stretch or mucosal stimulation applied to the central compartment inhibited NPY release in the orad compartment where ascending contraction was measured. NPY and the Y1-receptor agonist [Leu31, Pro34]NPY inhibited, whereas the selective Y1-receptor antagonist BIBP 3226 augmented ascending contraction and substance P (SP) release in the orad compartment induced by muscle stretch or mucosal stimulation. Neither agonist nor antagonist had any effect on descending relaxation or VIP release in the caudad compartment.There are some commonly used reagents with their cas registry numbers 82785-45-3 and 125580-28-1 in this article. The Y2-receptor agonist NPY13-36 and antagonist BIIE 0246 had no effect on peptide release or mech. response. The results indicate that suppression of a tonic inhibitory influence of NPY neurons on excitatory neurotransmitter release contributes substantially to the orad contractile phase of the peristaltic reflex. The effect of NPY on neurotransmitter release is mediated by Y1 receptors. .

Inhibition of stimulated cyclic AMP production by multiple neuropeptide Y receptors in the rat brainstem

Inhibition of stimulated cyclic AMP production by multiple neuropeptide Y receptors in the rat brainstem. Ny, Lars; Grundemar, Lars (Department of Clinical Pharmacology, Lund University Hospital, S-221 85, Lund, Swed.). Neuroscience Letters, 221(2,3), 113-116 (English) 1997 Elsevier. CODEN: NELED5. ISSN: 0304-3940. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Neuropeptide Y (NPY) has been shown to modulate blood pressure, heart rate and to inhibit the baroreceptor reflex at the level of nucleus tractus solitarius (NTS). The aim of this study was to examine effects of NPY and its related peptides on forskolin (1 mM)-stimulated cAMP prodn. in slices of the rat NTS.In this article, certain chemicals are used. Some of their cas registry numbers are 60-92-4 and 125580-28-1 Each peptide was present at 0.3 mM. Pretreatment with NPY inhibited the stimulated increase in cAMP levels in slices of rat NTS. Also [Pro34]NPY, an analog, which activates Y1, Y3 (and Y5) receptors inhibited the stimulated increase in cAMP levels. However, pretreatment with the Y1 receptor-selective antagonist BIBP 3226 (3 mM) did not affect the [Pro34]NPY-evoked inhibition of cAMP levels. In addn., [Leu31,Pro34]NPY, an Y1 (and PP1/Y4 and Y5) receptor agonist did not inhibit the stimulated increase in cAMP prodn. Also the Y2 receptor-selective agonist C2-NPY inhibited the stimulated elevation of cAMP levels, while peptide YY, which does not recognize Y3 receptors did not significantly affect the stimulated cAMP prodn. In conclusion, it seems that Y2 and Y3 receptors are coupled to inhibition of adenylate cyclase activity in the rat NTS. .