Reference

A Cyclodextrin Self-Assembled Monolayer (SAM) Based Surface Plasmon Resonance (SPR) Sensor for Enantioselective Analysis of Thyroxine

Shahgaldian, Patrick; Hegner, Martin; Pieles, Uwe (Institute of Physics, University of Basel, Basel CH-4056, Switz.). Journal of Inclusion Phenomena and Macrocyclic Chemistry, 53(1-2), 35-39 (English) 2005 Springer. CODEN: JIPCF5.Several substances with their cas registry numbers 100-74-3 and 125700-67-6 may be metioned in this study. ISSN: 1388-3127. DOCUMENT TYPE: Journal CA Section: 9 (Biochemical Methods) Heptakis {6-deoxy-6-[12-(thiododecyl)undecanamido]}-b-cyclodextrin has been produced by reaction of Heptakis(6-deoxy-6-amino)-b-cyclodextrin and 12-(thiododecyl)undecanoic acid using O-Benzotriazol-1-yl-N,N,N',N'-tetramethyluronium tetrafluoroborate (TBTU) as activating agent. Self-assembled monolayers of this macrocycle have been used in a surface plasmon resonance (SPR) sensor; it has been shown that this system is suitable to discriminate between D and L enantiomers of thyroxine, with a greater affinity for the D-enantiomer. .