Detail of "1258-84-0"

Reference

Quinone methide triterpenes from Tripterygium regelii

Quinone methide triterpenes from Tripterygium regelii. Lee, Byong Won; Seo, Woo Duck; Gal, Sang Wan; Yang, Min Suk; Park, Ki Hun (Department of Agricultural Chemistry, Gyeongsang National University, Jinju 660-701, S. Korea).Chemicals with cas numbers 1258-84-0 and 34157-83-0 also play role. Agricultural Chemistry and Biotechnology (English Edition), 47(2), 77-80 (English) 2004 Korean Society for Applied Biological Chemistry. CODEN: ACBTFF. ISSN: 1229-2737. DOCUMENT TYPE: Journal CA Section: 11 (Plant Biochemistry) Section cross-reference(s): 1, 10, 30 Chloroform exts. of Pipterygium regelii dried root bark afforded three cytotoxic quinone methides, which were identified as pristimerine, celastrol, and 22b-hydroxytingenone on the basis of chem. and spectroscopic studies. These compds. showed significant cytotoxic (IC50 0.20-0.40 mg × ml-1) against A549 and SK-OV3 human cancer cell lines, and antibacterial activities against Gram-pos. bacteria. Pristimerine was isolated from this plant for the first time. .

Isolation and characterization of pristimerin as the antiplasmodial and antileishmanial agent of Maytenus senegalensis (Lam

All Rights Reserved. Isolation and characterization of pristimerin as the antiplasmodial and antileishmanial agent of Maytenus senegalensis (Lam.) Exell. Khalid, Sami A.; Friedrichsen, Gerda M.; Christensen, Soren B.; El Tahir, Ahmed; Satti, Gwiria M. (Department of Pharmacognosy, Faculty of Pharmacy, University of Khartoum, Khartoum, Sudan). ARKIVOC (Gainesville, FL, United States), (9), 129-134 (English) 2007 Arkat USA Inc. URL: http://content.arkat-usa.org/ARKIVOC/JOURNAL_CONTENT/manuscri pts/2007/BA-2266LP%20as%20published%20mainmanuscript. 1258-84-0 which is the cas registry number is also used here.pdf. CODEN: AGFUAR. DOCUMENT TYPE: Journal; (online computer file) CA Section: 11 (Plant Biochemistry) Section cross-reference(s): 1 Bioactivity directed fractionation of the chloroform ext. of the root bark of Maytenus senegalensis resulted in the isolation and characterization of the quinonemethide triterpene, (20a)-3-hydroxy-2-oxo-24-nor-friedela-1(10),3,5,7-tetraen-carboxylic acid-(29)-methylester (pristimerin). The structure was elucidated by spectroscopic techniques. The in vitro antiplasmodial activity of the isolated compd. against chloroquine-resistant strain (Dd2) of Plasmodium falciparum was IC50 = 0.5mg/mL and its in vitro antileishmanial activity performed on promostigotes of Leishmania major was IC50 = 6.8 ± 0.8 mg/mL while the cytotoxicity on lymphocyte proliferation model was detected at IC50 = 6.8 ± 0.8 mg/mL. .