Detail of "12627-35-9"

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CAS Number:
12627-35-9
Name:
7,8-(Epoxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno[4',4'a]-1-benzopyrano[5',6':6,7]indeno[1,2-b]indole-3,4b,7d(5H,7H)-triol,12-chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14b,14c,17,17-tetramethyl-10-methylene-2-(1-methylethenyl)-,(2R,3S,3aR,4aS,4bS,6aR,7S,7dR,8R,9aR,14bS,14cR,16aS)-
Molecular Structure:
Formula:
C37H44 Cl N O6
Molecular Weight:
634.27
Deleted CAS:
12679-82-2
Synonyms:
Penitrem A;NSC 354845;Tremortin A;[2R-(2a,3a,3aa,4aS*,4bb,6aa,7a,7db,8b,9ab,14bb,14ca,16ab)]-12-Chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14b,14c,17,17-tetramethyl-10-methylene-2-(1-methylethenyl)-7,8-(epoxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno[4',4'a]-1-benzopyrano[5',6':6,7]indeno[1,2-b]indole-3,4b,7d(5H,7H)-triol;
Density:
1.44 g/cm³
Boiling Point:
°Cat760mmHg
Flash Point:
°C
Hazard Symbols:
T+
Risk Codes:
26/27/28
Safety:
Poison by ingestion and intraperitoneal routes. An experimental teratogen. When heated to decomposition it emits very toxic fumes of Cl⁻ and NO_x. Details
Transport Information:
UN 2811 6

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PENITREM A

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Effect of penitrem A on mouse liver composition: Effect of penitrem A on mouse liver composition. Hayes, A. Wallace; Phillips, Richard D.; Wallace, Linda C. (Dep. Pharmacol. Toxicol., Univ. Mississippi Med. Cent., Jackson, Miss., USA). Toxicon, 15(4), 293-300 (English) 1977. CODEN: TOXIA6. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) A single dose of penitrem A [12627-35-9] (2.5 mg/kg, i.p.) in propylene glycol caused a 53% decrease in mouse liver DNA. Total liver lipid was increased 178% at 24 h. A disappearance of free fatty acids concomitant with an increase in liver triacylglycerols was also detected. Total liver glycogen [9005-79-2] decreased 68% by 6 h after similar treatment but returned to pretreatment levels by 48 h. Liver sections from animals given 2.5 mg per kg penitrem A showed slight degranulation of centrolobular hepatocytes. In contrast, liver glycogen in fasted animals was increased 92%, 72 h after dosing with 2.5 mg per kg penitrem A. Four consecutive daily i.p. administrations, totaling 4.0 mg per kg of penitrem A, resulted in reduced food consumption and a suppression of animal growth. DNA levels were significantly lower, whereas glycogen was significantly elevated in the liver of these animals. Cholesteryl esters in livers obtained from this group of treated animals were the only lipids which were significantly elevated.

Production of Penitrem A and of an unidentified toxin by Penicillium lanoso-coeruleum isolated from weevil-damaged pecans: Production of Penitrem A and of an unidentified toxin by Penicillium lanoso-coeruleum isolated from weevil-damaged pecans. Wells, John M.; Cole, Richard J. (Southeast. Fruit Tree Nut Res. Stn., USDA, Byron, Ga., USA). Phytopathology, 67(6), 779-82 (English) 1977. CODEN: PHYTAJ. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Section cross-reference(s): 17 CHCl3 exts. of P. lanoso-coeruleum isolated from weevil-damaged pecans and grown on shredded wheat-yeast ext.-sucrose medium were toxic to 1-day-old cockerels, producing sustained tremors and convulsions prior to mortality. Two toxic fractions were sepd. from CHCl3 exts. by sequential elution from silica gel columns with diethyl ether and acetone. Crystals obtained from the ether fraction was identified as Penitrem A [12627-35-9] by chromatog., spectral and color reaction. Crystals from the acetone fraction had Rf values in TEF of 0.1 or less, UV maxima at 317 and 245 nm, and IR maxima of 1,675 and 1,400 cm-1. The chem. identity of the toxin in the acetone fraction is unknown.