CAS No.1263-89-4,PAROMOMYCIN SULFATE Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	1263-89-4
Name:	PAROMOMYCIN SULFATE

Formula:	C₂₃H₄₅N₅O₁₄•H₂O₄S
Molecular Weight:	713.81
Synonyms:	Aminosidine Sulphate;Paromomycin sulfate salt;Humatin (TN);Paromomycin sulfate (JAN/USP);Prestwick_1023;D-Streptamine,O-2-amino-2-deoxy-R-Dglucopyranosyl-( 1f4)-O-[O-2,6-diamino-2,- 6-dideoxy-a-L-idopyranosyl-(1f3)-a-Dribofuranosyl-( 1f5)]-2-deoxy-,sulfate (salt);Paromomycin sulfate;Gabbroral;Humatin;5-amino-6-[4,6-diamino-2-[(3S,4S,5R)-4-[3-amino-6-(aminomethyl)-4,5-dihydroxy-oxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxy-cyclohexyl]oxy-2-(hydroxymethyl)oxane-3,4-diol; sulfuric acid;(2R,3S,4R,5R,6S)-5-amino-6-[(1R,2S,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4R,5R)-4-[(2R,3R,4R,5R,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxy-oxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxy-cyclohexyl]oxy-2-(hydroxymethyl)oxane-3,4-diol; sulfuric acid;
EINECS:	215-031-7
Melting Point:	>200oC
Boiling Point:	939.8 °C at 760 mmHg
Flash Point:	522.2 °C
Solubility:	water: 50 mg/mL
Appearance:	powder
Hazard Symbols:	Xi
Risk Codes:	23/24/25-61-36/37/38
Safety:	26-36/37-45-38-36
PSA:	430.30000
LogP:	-4.93220

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Specification

This chemical is called Paromomycin sulphates, and it's also named as D-Streptamine, O-2-amino-2-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(O-2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl-(1-3)-beta-D-ribofuranosyl-(1-5))-2-deoxy-, sulfate (salt). With the classification codes Anthelmintic; Anti-amebic; Drug / Therapeutic Agent; Mutation data, its product categories are Antibiotics A to; A ntibiotics by Application; Chemical Structure Class; Genetic Marker Selection Antibiotics; Interferes with Protein Synthesis Spectrum of Activity; Mechanism of Action. The CAS registry number of this chemical is 1263-89-4. Additionally, it should be stored at 0-6°C where the room is dry and ventilated. Keep the Paromomycin sulphates away from the oxidants.

Other characteristics of the Paromomycin sulphates can be summarised as followings: (1)ACD/LogP: -3.27; (2)# of Rule of 5 Violations: 3; (3)ACD/LogD (pH 5.5): -10.06; (4)ACD/LogD (pH 7.4): -8.33; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 19; (10)#H bond donors: 18; (11)#Freely Rotating Bonds: 22; (12)Polar Surface Area: 145.42 Å²; (13)Flash Point: 522.2 °C; (14)Enthalpy of Vaporization: 155.13 kJ/mol; (15)Boiling Point: 939.8 °C at 760 mmHg; (16)Vapour Pressure: 0 mmHg at 25°C.

Uses of this chemical: The Paromomycin sulphates is an oligosaccharide antibiotic produced by various streptomyces. It's aminoglycoside antibiotics. Generally, this chemical is used on the treatment of bacillary dysentery and other gastrointestinal infections. It can also cure amoebic dysentery. Moreover, you can find that it used on fire extinguishing agents, dry powder, foam, sand, carbon dioxide and water spray.

When you are using this chemical, please be cautious about it as the following: This chemical is irritating to eyes, respiratory system and skin. It may cause harm to the unborn child. You should wear suitable protective clothing if you use it. In case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
1.InChI: InChI=1/C23H45N5O14.H2O4S/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;1-5(2,3)4/h5-23,29-36H,1-4,24-28H2;(H2,1,2,3,4)/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18?,19-,20-,21-,22-,23?;/m1./s1
2.Smiles:O1[C@H](O[C@H]2[C@@H](O)[C@@H](O[C@H]3[C@@H](O[C@@H]4[C@H](N)[C@H]([C@@H]([C@H](O4)CO)O)O)[C@@H](N)C[C@H](N)[C@@H]3O)O[C@@H]2CO)[C@H](N)[C@@H](O)[C@@H]([C@@H]1CN)O.OS(=O)(O)=O

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	subcutaneous	1700mg/kg (1700mg/kg)		Chemotherapy Vol. 16, Pg. 105, 1968.
monkey	LDLo	intravenous	93mg/kg (93mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Antibiotics and Chemotherapy Vol. 9, Pg. 730, 1959.
mouse	LD50	intracrebral	22300ug/kg (22.3mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Chemotherapy Vol. 16, Pg. 114, 1968.
mouse	LD50	intramuscular	438mg/kg (438mg/kg)		Japanese Journal of Antibiotics. Vol. 36, Pg. 644, 1983.
mouse	LD50	intraperitoneal	750mg/kg (750mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Chemotherapy Vol. 16, Pg. 114, 1968.
mouse	LD50	intravenous	90mg/kg (90mg/kg)		Therapie. Vol. 16, Pg. 184, 1961.
mouse	LD50	oral	23500mg/kg (23500mg/kg)		Japanese Journal of Antibiotics. Vol. 36, Pg. 644, 1983.
mouse	LD50	subcutaneous	123mg/kg (123mg/kg)		Therapie. Vol. 16, Pg. 184, 1961.
rat	LD50	intramuscular	1200mg/kg (1200mg/kg)		Drugs in Japan Vol. 6, Pg. 595, 1982.
rat	LD50	intravenous	181mg/kg (181mg/kg)		Antibiotics and Chemotherapy Vol. 9, Pg. 730, 1959.
rat	LD50	oral	21620mg/kg (21620mg/kg)		Drugs in Japan Vol. 6, Pg. 595, 1982.
rat	LD50	subcutaneous	870mg/kg (870mg/kg)	PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE	Chemotherapy Vol. 16, Pg. 114, 1968.