Detail of "12687-98-8"

CAS Number:
12687-98-8
Name:
Oxacyclohexatriaconta-3,5,7,9,11,13-pentaene-2,22,28-trione,14,16,18,20,24,26-hexahydroxy-3-methyl-36-(1-methylethyl)-
Molecular Structure:
Formula:
C39H62 O10
Molecular Weight:
0
Synonyms:
DermostatinA, 16,34-didemethyl-21,27,29,31-tetradeoxy-12,13,32,33-tetrahydro-13-hydroxy-2-methyl-21,27-dioxo-;Oxacyclohexatriacontane, dermostatin A deriv.; Roseofungin; Rozeofungin
Safety:
A poison by intraperitoneal and intravenous routes. When heated to decomposition it emits acrid smoke and irritating vapors. Details

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Pharmacology of the new antifungal antibiotic roseofungin: Pharmacology of the new antifungal antibiotic roseofungin. Utepbergenova, R. K.; Filimonova, L. A.; Shakiev, S. Sh. (Alma-At. Gos. Med. Inst., Alma-Ata, USSR). Nek. Probl. Farm. Nauki Prakt., Mater. S'ezda Farm. Kaz., 1st, 213-15. Edited by: Dubinin, N. S. Nauchn. O-vo. Farm. Kaz.: Alma-Ata, USSR. (Russian) 1975. CODEN: 35IIA6. DOCUMENT TYPE: Conference CA Section: 1 (Pharmacodynamics) Roseofungin (I) [12687-98-8] (2-32 mg/kg) injected i.v. into cats increased arterial pressure for 10-30 min and decreased respiration rate; it did not affect the electrocardiogram. In dogs I at 5-10 mg/kg increased arterial pressure and decreased respiration rate but also caused tachycardia. The hypertensive effect of I was not owing to an effect on the sympathetic nervous system.

Virus-inhibiting properties of roseofungin, a carbonyl conjugated pentaene: Virus-inhibiting properties of roseofungin, a carbonyl conjugated pentaene. Shneider, M. A.; Stilbans, E.; Rachkovskaya, L. A.; Vetlugina, L. A.; Nikitina, E. T. (All-Union Res. Technol. Inst. Antibiot. Med. Enzymes, Leningrad, USSR). Antibiotiki (Moscow), 29(5), 344-9 (Russian) 1984. CODEN: ANTBAL. ISSN: 0003-5637. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The anti-influenza activity of roseofungin [12687-98-8], a polyenic macrolide antibiotic, was studied in vitro on surviving fragments of chick embryo chorionallantoic membranes and in ovo on growing chick embryos. The antibiotic activity against influenza A and B viruses was high. The activity of roseofungin against influenza A virus did not differ from that of remantadine, the most active inhibitor of influenza virus reprodn. However, the activity of roseofungin against influenza B virus was an advantage of this antibiotic over remantadine, which had practically no effect on this virus type. A statistically significant protective effect of roseofungin was shown on animals with exptl. influenza. The study on the antiviral activity of roseofungin against the DNA-contg. variolovaccine virus revealed that it markedly inhibited virus. Roseofungin had a pronounced inhibitory effect on cell neoplastic transformation induced by the RNA contg. oncogenic virus of Rous sarcoma.