Detail of "127-77-5"

CAS Number:
127-77-5
Name:
Benzenesulfonamide,4-amino-N-phenyl-
Superlist Name:
Sulfabenz
Molecular Structure:
Formula:
C₁₂H₁₂N₂O₂S
Molecular Weight:
248.30
Synonyms:
Sulfanilanilide(6CI,7CI,8CI);4-(Phenylsulfamoyl)benzenamine;4-Amino-N-phenylbenzenesulfonamide;4-Aminobenzenesulfonanilide;N-Phenyl4-aminobenzenesulfonamide;N1-Phenylsulfanilamide;NSC 2619;Sulfa Vet;Sulfabenz;p-Amino-N-phenylbenzenesulfonamide;p-Aminobenzenesulfonanilide;
EINECS:
204-865-7
Density:
1.373 g/cm³
Boiling Point:
445.1 °C at 760 mmHg
Flash Point:
223 °C

Display：

4-Amino-N-phenyl-benzenesulfonamide

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Studies on synergistic behavior and pharmacokinetics of sulfonamide/trimethoprim combinations: Studies on synergistic behavior and pharmacokinetics of sulfonamide/trimethoprim combinations. IV. A comparative study on potentiating the trimethoprim effect by various sulfonamides and critical observations on its dosing. Seydel, J. K.; Wempe, E. (Forschungsinst. Borstel, Inst. Exp. Biol. Med., Borstel, Ger.). Arzneim.-Forsch., 27(8), 1521-32 (German) 1977. CODEN: ARZNAD. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 3 3-Sulfa-5-methylisoxazole (I) [723-46-6], 2-sulfa-4,5-dimethyloxazole (II) [729-99-7], 2-sulfapyridine [144-83-2], sulfabenz [127-77-5], and sulfanilamide [63-74-1] had min. inhibitory concns. for Escherichia coli of 0.8, 3.5, 7, 16, and 128 .mu.moles/L; that of trimethoprim (III) [738-70-5] was 0.17 .mu.moles/L. The sulfonamides potentiated the inhibitory effect of III on E. coli at low doses but at high concns. antagonized the inhibitory effects of III. Pharmacokinetics of II-III [57197-43-0] and I-III [8064-90-2] combinations in human subjects following oral administration were studied. The suggested dose for the II-III combination seems to be sufficient and the dosage regimen correct (2 tablets initially; 1 tablet/12 h) whereas the amt. of I in the dose (400 mg) proposed for its combination with III (80 mg) seems high and the dosage scheme (2 tablets/12 h) incorrect.

Monoazo dyes: Monoazo dyes. Brierley, David; Ridyard, Denis Robert Annesley; Yelland, Michael (Imperial Chemical Industries Ltd., Engl.). Ger. Offen. DE 2714740 6 Oct 1977, 10 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: C09B029-38. PRIORITY: GB 76-13301 1 Apr 1976. DOCUMENT TYPE: Patent CA Section: 40 (Dyes, Fluorescent Whitening Agents, and Photosensitizers) Azo dye I [64768-02-1], dyeing polyamide fibers a fast yellow shade, is prepd. by diazotizing 4-aminobenzenesulfonanilide [127-77-5] and coupling with 1-(4-sulfophenyl)-3-methyl-5-pyrazolone [89-36-1].