Reference

Atomic absorption determination of certain sulfonamides via their metal complexes

Atomic absorption determination of certain sulfonamides via their metal complexes. Ayad, M.; Abd El Aziz, L.; El Kheir, A. (Fac. Pharm., Zazazig Univ., Zagazig, Egypt). Anal. Lett., 16(B16), 1335-42 (English) 1983. CODEN: ANALBP. ISSN: 0003-2719. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Sulfathiazole [72-14-0], sulfadiazine [68-35-9], and sulfamerazine [127-79-7] were detd. by at. absorption spectroscopy as their Co2+, Cd2+, and Cu2+ chelates, resp. Aliquots of the drug solns. were treated by CoSO4, CdSO4, or Cu(OAc)2, resp., the formed ppt. 22537-48-0 and 15158-11-9 are cas registry numbers of chemicals which are used as reagents here. sepd., and the amt. of the corresponding metal was detd. in the ppt. The percentage recoveries were 99.5-100.6%. The min. amts. of sulfa drug detected was 2 mg. .

In vitro synergism between some sulfonamides and trimethoprim

In vitro synergism between some sulfonamides and trimethoprim. Genova, R. (Lab. Ric., Ist. De Angeli, Milan, Italy). G. Ital. Chemioter., 21(2), 159-68 (Italian) 1974. CODEN: GICTAL. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) Trimethoprim (I) [738-70-5] potentiated the antibacterial activity of all 6 sulfonamides tested (sulfathiazole (II) [72-14-0], sulfamethoxazole [723-46-6], sulfamethoxypyridazine [80-35-3], sulfadiazine [68-35-9], sulfamerazine [127-79-7], and sulfisoxazole [127-69-5]) against 19 strains of gram-pos. and gram-neg. bacteria, including those resistant to the sulfonamides alone. The degree of potentiation was the same for all the sulfonamides against a given bacterial strain. Comparison of 2 methods, the min.In this experiment, several chemicals are used like 72-14-0 and 738-70-5 inhibitory concn. test and the agar diffusion test, showed that both were equally suited to measuring the synergism between I and the sulfonamides. .