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Detail of "127045-41-4"

  • CAS Number:
  • 127045-41-4
  • Name:
  • Pazufloxacin

  • Molecular Structure:
  • Formula:
  • C16H15FN2O4
  • Molecular Weight:
  • 318.30
  • Synonyms:
  • Pasil;Pasil (TN);PZFX;7H-Pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid, 2,3-dihydro-10-(1-aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-, (S)-;7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6- carboxylic acid,10-(1-aminocyclopropyl)-9- fluoro-2,3-dihydro-3-methyl-7-oxo-,(3S)-;T 3761;(-)-(3S)-10-(1-Aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid;7H-Pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (S)-;T-3761;Pazufloxacin Mesylas;Pazufloxaxin;(S)-10-(1-aminocyclopropyl)-9-fluoro-3-methy...;
  • Density:
  • 1.56 g/cm3
  • Melting Point:
  • 269-271 °C
  • Boiling Point:
  • 531.5 °C at 760 mmHg
  • Flash Point:
  • 275.2 °C
  • Appearance:
  • like white to light yellow crystalline
  • Hazard Symbols:
  • HarmfulXn,CorrosiveC,FlammableF
  • Risk Codes:
  • 20/21/22
  • Safety:
  • 36/37 Details

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CAS No.127045-41-4 PazufloxacinCompetitive Product

Pazufloxacin base,for Methanesulfonate

Supplier:hangzhou verychem science and technology co.ltd [ China (Mainland)]

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910Integral
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Address:F1003, 753 Shenhua Road, hangzhou, china

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CAS No.127045-41-4 PazufloxacinCompetitive Product

Supplier:Changzhou Highassay Chemical Co., Ltd [ China (Mainland)]

Platinum
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915Integral
915

Tel:+86-519-83200395 +86-0592-7256591

Address:XIXIASHU TOWN, XINBEI DISTRICT, CHANGZHOU, JIANGSU

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CAS No.127045-41-4 Pazufloxacin

Pazufloxacin

Supplier:Anhui Charm Imp.&Exp.Co., Ltd [ China (Mainland)]

Platinum
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925Integral
925

Tel:86 551 5316260

Address:No. 211,XiangZhang Road,Hefei City,Anhui Province,China

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CAS No.127045-41-4 Pazufloxacin

Assay:99%  Appearance:White or lig...

Supplier:Taiyuan RHF CO., ltd. [ China (Mainland)]

Platinum
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2160Integral
2160

Tel:0351-7436719

Address:Shuangta South Alley 46,2-1, YingZe Area,Taiyuan, ShanXi

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CAS No.127045-41-4 Pazufloxacin

Pazufloxacin

Supplier:TCS INDUSTRY LIMITED [ China (Mainland)]

Platinum
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1590Integral
1590

Tel:0512-68091917

Address:Room 917, Jinfeng international, Jinfeng road

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CAS No.127045-41-4 Pazufloxacin

127045-41-4

Supplier:Jinan Wedo Industrial Co., Ltd. [ China (Mainland)]

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1590Integral
1590

Tel:+86-531-88873473

Address:No.36, Gongyenan Road, Jinan China

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CAS No.127045-41-4 Pazufloxacin

Assay:98%

Supplier:Hangzhou Dayangchem Co., Ltd. [ China (Mainland)]

Platinum
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ISO 3875Integral
3875

Tel:+86-571-88938639

Address:B/2601 Fuli Building, 328# WenEr Rd. Hangzhou City 310012 China

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CAS No.127045-41-4 Pazufloxacin

STANDARD SFDA Antibiotics

Supplier:BORI International Enterprises (Nanjing) Co., Ltd [ China (Mainland)]

Silver
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1310Integral
1310

Tel:0086-25-5220 9840

Address:Rm., 235 & 202, Grand City Inn, 68# Jiankang road, Nanjing 210001, China

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CAS No.127045-41-4 Pazufloxacin

  Appearance:White or lig...

Formula: C16H15FN2O4 Molecular Weight:318.30

Supplier:orient pharmaceutical co.,ltd [ China (Mainland)]

900Integral
900

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Address:chaoyang district,beijing,china

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CAS No.127045-41-4 Pazufloxacin

Pazufloxacin

Min. Order:1Kilogram

Supplier:Shenyang Zhongchen Chemical Technology Development Co., Ltd [ China (Mainland)]

317Integral
317

Tel:13390137933 / +86-24-86412789

Address:Korea New Castle, No.3 Changjiang South Street Huanggu District, Shenyang

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CAS No.127045-41-4 Pazufloxacin

(S)-10-(1-Aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid

Supplier:Wuhan Seraphic Technology Co.,Ltd [ China (Mainland)]

660Integral
660

Tel:0086-13507189111 27-88779072

Address:Room 6-1-1103, JingAnShangCheng, 8#JingAn Road, WuChang District ,

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CAS No.127045-41-4 Pazufloxacin

Main quality index: [Property]:White-like to light yellow powdery solid. [Melting point]:267-272°C [Content]:≥98.5% [Specific rotation]:-77- -82° [Loss on drying]:≤0.5% [Residue on ignition]:≤0.2% [ Content of heavy metal]:≤20PPM [Content of isomer]:≤1.0% Main use:

Supplier:Nanjing Guangtong Pharmachemical Co., Ltd [ China (Mainland)]

128Integral
128

Tel:+86-25-57837002

Address:64 Guangtong Road, Dongba Town, Gaochun County, Nanjing city

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CAS No.127045-41-4 Pazufloxacin

Pazufloxacin,Pazufloxacin mesylate

Supplier:Manus Aktteva Biopharma LLP [ India]

610Integral
610

Tel:+ 91 79 65123395, 26463395

Address:303, 3rd Floor, Royale Manor, Law Garden, Ellisbridge, Ahmedabad - 380006, Gujarat, India

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CAS No.127045-41-4 Pazufloxacin

Supplier:Hubei Hengluyuang Technology Co.,Ltd [ China (Mainland)]

360Integral
360

Tel:027-51835635

Address:4F-3,Chemical industrial park,Huangzhou Area, Huanggang City,Hubei Province

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CAS No.127045-41-4 Pazufloxacin

Supplier:HangZhou Puris Biotechnology Ltd [ China (Mainland)]

10Integral
10

Tel:+86-571-56715086

Address:Wantang RD262, Hangzhou,Zhejiang P.R,China

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CAS No.127045-41-4 Pazufloxacin

Supplier:Jiangxi Henghui Pharmaceutical Chemical Co.,Ltd. [ China (Mainland)]

52Integral
52

Tel:13576809088

Address:jiangxi

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CAS No.127045-41-4 Pazufloxacin

Supplier:Jointown Pharmaceutical Group Co., Ltd. [ China (Mainland)]

386Integral
386

Tel:86-27-59889904,84630900

Address:No.8 Longyang Avenue,Hanyang District,Wuhan, Hubei Province

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CAS No.127045-41-4 Pazufloxacin

Supplier:Vitalpharms Co,.Ltd. [ China (Mainland)]

550Integral
550

Tel:+86-579-82476589

Address:2/F, 3# Buliding, 169 Shihua Rd. West, Zhuhai, Guangdong, China.

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CAS No.127045-41-4 Pazufloxacin

Supplier:Wuxi Weikang Curative Chemical Co., Ltd. [ China (Mainland)]

316Integral
316

Tel:86-510-88203456

Address:41 Middle Chunchao Road, Dongting, Wuxi, Jiangsu, China

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Reference

Pharmacokinetics of pazufloxacin injection in healthy volunteers
All Rights Reserved. Pharmacokinetics of pazufloxacin injection in healthy volunteers. Zhou, Lingjie; Gu, Lihua; Wang, Yijian; Liang, Jianying; Huang, Yihui; Huang, Zhongyi (School of Pharmacy, Fudan University, Shanghai 200032, Peop. Rep. China). Fudan Xuebao, Yixueban, 32(6), 718-720, 728 (Chinese) 2005 Fudan Xuebao, Yixueban Bianji Weiyuanhui. CODEN: FXYUAO. ISSN: 1672-8467. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Totally 36 healthy adult male volunteers participated in this 3 dosages expt. (150, 300, 600 mg, 12 volunteers/group). The volunteers were randomly assigned to 3 treatment groups and were given resp. the dose of 150, 300, 600 mg by means of i.v. infusion. Serum was sepd. and the concn. of pazufloxacin in human serum was detd. by HPLC using fluorescence detector after protein had been deposited. The values of Cmax and tmax were directly detected, and AUC was calcd. by linear trapezoid method. The main pharmacokinetic parameters of pazufloxacin of 3 dosages (150, 300, 600 mg) were as follow: AUC0-t (mg×h×mL-1) was 7.66±1.65, 14.92±3.75, 29.88±4.66 resp.; AUC0-¥ (mg×h×mL-1) was 8.19±1.73, 15.42±3.73, 30.55±4.83 resp.; Cmax (mg×mL-1) was 3.55±1.21, 8.16±2.51, 17.38±5.42 resp.; t1/2 (h) was 2.52±0. 127045-41-4 which is the cas registry number is also used here.16, 2.18±0.18, 2.12±0.13 resp.; Ke (h-1) was 0.28±0.02, 0.32±0.03, 0.34±0.03 resp.; V(L) was 40.95±6.05, 40.27±9.95, 36.50±4.98 resp.; Cl (mg/h) was 11.51±1.90, 12.88±2.85, 12.34±2.14 resp.; MRT (h) was 2.77±0.23, 2.43±0.21, 2.45±0.23 resp.; tmax of pazufloxacin was 0.5 h for all of these 3 dosages. No significant difference in pharmacokinetic parameters, such as tmax, t1/2, Ke, V, Cl, MRT, AUC0-t/dose, AUC0-¥/dose and Cmax/dose was shown among the three dose groups, and a linear pharmacokinetic was featured. .
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