Detail of "12772-57-5"

Reference

Cytotoxic activity of macrocyclic substances from fungi

Cytotoxic activity of macrocyclic substances from fungi. Horakova, K.; Betina, V. (Chem. Technol. Fac., Slovak Polytech. Univ., Bratislava, Czech.). Neoplasma, 24(1), 21-7 (English) 1977. CODEN: NEOLA4. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Of 7 macrocyclic fungal metabolites tested for cytotoxicity toward HeLa cells, cyanein [20350-15-6] and monorden [12772-57-5] were the most effective; both compds. had an ED50 value of 7 .times. 10-8M. Cytochalasin A [14110-64-6], cytochalasin B [14930-96-2], and cytochalasin D [22144-77-0] were less active, with ED50 values in the range 1.2 .times. 10-6-2.1 .times. 10-6M. Curvularin [10140-70-2] and zearalenone [17924-92-4] were the least effective cytotoxic agents, having ED50 values of 2 .times. 10-4M and 7.There are some commonly used reagents with their cas registry numbers 10140-70-2 and 17924-92-4 in this article.5 .times. 10-5M, resp. Biol. activity is discussed in relation to the chem. structures of these compds. .

Interactions of geodin antibiotics and some other naturally occuring a,b-unsaturated carbonyl compounds with low molecular thiols and thiolproteins

Interactions of geodin antibiotics and some other naturally occuring a,b-unsaturated carbonyl compounds with low molecular thiols and thiolproteins. Sturdik, Ernest; Drobnica, Ludovit; Sladkova, Vlasta; Krchnava, Edita (Dep. Tech. Microbiol. Biochem., Slovak Polytech. Univ., Bratislava 812 37, Czech.). Biologia (Bratislava), 38(12), 1229-41 (English) 1983. CODEN: BLOAAO. ISSN: 0006-3088. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Geodin (I) [427-63-4], trypacidin (II) [1900-29-4], plumbagin (III) [481-42-5], terreic acid [121-40-4] and monorden [12772-57-5] were potent inhibitors of glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12) [9001-50-7] and other sulfhydryl (SH) enzymes, glucose-6-phosphate dehydrogenase (EC 1.1.1.49) [9001-40-5], glutathione reductase (EC 1.6.4.2) [9001-48-3] and malate dehydrogenase (EC 1.1.1.37) [9001-64-3]. The expts. with reduced glutathione [70-18-8], as the model low mol. thiol, showed that these compds. were reactive thiol-combining agents. The ability to react with SH groups is discussed in the light of the biol. activities of these naturally occurring a,b-unsatd. carbonyl compds. Structure-activity relations are discussed.