Detail of "127869-51-6"

MSDS Download
CAS Number:
127869-51-6
Name:
C-Type natriureticpeptide-22 (swine) (9CI)
Molecular Structure:
Formula:
C93H157 N27 O28 S3
Molecular Weight:
2197.6
Synonyms:
C-Typenatriuretic factor-22 (swine);1,2-Dithia-5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-hexadecaazacyclotripentacontane,cyclic peptide deriv.; 1-22 Human C-type natriuretic peptide; 7: PN:US20090011997 SEQID: 5 claimed protein; Human C-type natriuretic peptide(1-22);Porcine C-type natriuretic peptide(1-22); Rat C-type natriuretic peptide(1-22)

Please post your buying leads,so that our qualified suppliers will soon contact you!
*Required Fields

Isolation of physiologically active peptide originating in hog as natriuretic and antihypertensive: Isolation of physiologically active peptide originating in hog as natriuretic and antihypertensive. Matsuo, Hisayuki (Japan ). PCT Int. Appl. WO 9116342 A1 31 Oct 1991,28 pp. DESIGNATED STATES: W: JP, US; RW: AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE. (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: C07K007-10. ICS: A61K037-24. APPLICATION: WO 91-JP527 20 Apr 1991.Several substances with their cas registry numbers 7440-09-7 and 127869-51-6 may be metioned in this study. PRIORITY: JP 90-105047 20 Apr 1990. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) The title peptide (I) is isolated from a pig's brain. I has both natriuretic and hypotensive activities and also activities of inhibiting the growth of vascular smooth muscle cells and producing cGMP and thus is useful for treating cardiac, renal, hepatic edema, hypertension, congestive failure, acute and chronic renal insufficiency, and atherosclerosis. I at 80 nmol/kg i.v. increased urine, Na+, K+, and Cl- secretion by 251, 286, 167, and 301 % and lowered the blood pressure by 16.7 % in rats. .

Cloning and sequence analysis of a cDNA encoding a precursor for rat C-type natriuretic peptide (CNP): Cloning and sequence analysis of a cDNA encoding a precursor for rat C-type natriuretic peptide (CNP). Kojima, Masayasu; Minamino, Naoto; Kangawa, Kenji; Matsuo, Hisayuki (Dep. Biochem., Miyazaki Med. Coll., Kiyotake 889-16, Japan). FEBS Lett., 276(1-2), 209-13 (English) 1990. CODEN: FEBLAL. ISSN: 0014-5793. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Genetics) Section cross-reference(s): 2, 13 Recent identification of a C-type natriuretic peptide (CNP) in porcine brain strongly suggested that a third member of the natriuretic peptide family still remains to be identified in other species of mammals. A cDNA encoding a precursor for rat CNP was cloned from a rat brain cDNA library and sequenced. The precursor was a 126-residue peptide, carrying a 23-residue signal sequence at the N-terminus and the known porcine CNP-53 sequence at the C-terminus. By RNA blot anal., rat CNP mRNA was expressed exclusively in the brain, implying that CNP may function in the central nervous system as a neuropeptide. 127869-51-6 and 137800-23-8 are just another two chemicals used in this study. .