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128-62-1

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Basic Information
CAS No.: 128-62-1
Name: Narcotine
Article Data: 26
Molecular Structure:
Molecular Structure of 128-62-1 (Narcotine)
Formula: C22H23NO7
Molecular Weight: 413.427
Synonyms: 1(3H)-Isobenzofuranone,6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-,[S-(R*,S*)]-;Narcotine (7CI,8CI);(-)-Narcotine;(-)-a-Narcotine;Capval;Coscopin;L-a-Noscapine;Longactin;Longatin;Methoxyhydrastine;NSC 5366;Narcompren;Narcosine;Narcotin;Narcotussin;Nectadon;Nicolane;Nipaxon;Noscapin;Noscapine;Opian;Opianin;Opianine;Tusscapine;Vadebex;a-Narcotine;
EINECS: 204-899-2
Density: 1.333 g/cm3
Melting Point: 174-176 °C(lit.)
Boiling Point: 565.316 °C at 760 mmHg
Flash Point: 295.692 °C
Solubility: 302.9mg/L(25 oC)
Appearance: Crystalline solid
Hazard Symbols: HarmfulXn
Risk Codes: 22
Safety: 24/25
Transport Information: UN 1544
PSA: 84.48000
LogP: 2.86840
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Chemistry

Product Name: Narcotine (128-62-1)


Molecular Formula: C22H23NO7
Molecular Weight: 413.42g/mol
Mol File: 128-62-1.mol
Einecs: 204-899-2
Melting Point: 174-176 °C(lit.)
Alpha:  -200 ° (c=1 in chloroform)
Boiling point: 565.3°C at 760mmHg
Density: 1.332g/cm3
Product Categories: Intermediates and Fine Chemicals; Pharmaceuticals; Asymmetric Synthesis; Chiral Building Blocks; Complex Molecules
Synonyms of  Narcotine (128-62-1): 2,3,4-tetrahydroisoquinaline ; [S-(R*,S*)]-6,7-Dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-1(3H)-Isobenzofuranone ; 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-, [S-(R*,S*)]- ; 1-alpha-Narcotine ; 5-g)isoquinolin-5-yl)-,(s-(r*,s*))-3-dioxolo(4;5-g]isoquinolin-5-yl)-,[s-(theta,s)]-3-dioxolo[4;6,7-Dimethoxy-3-(4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-2-benzofuran-1(3H)-one ; 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1(3h)-isobenzofuranon .

Uses

Bronchial spasm of antitussives.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 73200ug/kg (73.2mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Oyo Yakuri. Pharmacometrics. Vol. 2, Pg. 323, 1968.
mouse LD50 intraperitoneal 960mg/kg (960mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 24, Pg. 2331, 1982.
mouse LD50 intravenous 83mg/kg (83mg/kg)   Toxicology and Applied Pharmacology. Vol. 3, Pg. 96, 1961.
mouse LD50 oral 853mg/kg (853mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 24, Pg. 2331, 1982.
mouse LD50 subcutaneous 725mg/kg (725mg/kg)   Russian Pharmacology and Toxicology Vol. 31, Pg. 338, 1968.
rat LD50 oral 1520mg/kg (1520mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 24, Pg. 2331, 1982.

Safety Profile

Moderately toxic by ingestion and subcutaneous routes. Mutation data reported. An antitussive. When heated to decomposition it emits toxic fumes of NOx.
Safety Information of Narcotine (128-62-1):
Hazard Codes: Xn
Risk Statements: 22 
22:  Harmful if swallowed

Specification

 Narcotine (128-62-1) is a colorless crystalline powder or glossy prism-like or flaky crystal; odorless, tasteless. Is almost insoluble in water, slightly soluble in alcohol and ether, soluble in chloroform.