Reference

Effects of ranitidine bismuth citrate on gastric acid secretion and gastrin release in subjects with and without Helicobacter pylori infection

Effects of ranitidine bismuth citrate on gastric acid secretion and gastrin release in subjects with and without Helicobacter pylori infection. Ciociola, A. A.; Webb, D. D.; Heath, A.; Walsh, J. H. (Glaxo Wellcome Inc., Research Triangle Park, NC 27709, USA). Alimentary Pharmacology and Therapeutics, 10(6), 905-912 (English) 1996 Blackwell. CODEN: APTHEN. ISSN: 0269-2813. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Ranitidine bismuth citrate is a novel antiulcerant that provides the antisecretory activity of ranitidine and the gastric mucosal protection and antibacterial properties of bismuth. This randomized, double-blind, placebo-controlled study evaluated the effects of single doses of ranitidine bismuth citrate 200 mg, 400 mg and 800 mg and ranitidine hydrochloride 150 mg on gastrin release and suppression of gastric acid secretion, and compared acid secretory profiles and gastrin release between Helicobacter pylori-neg. and -pos. patients. Plasma gastrin concns. were detd. by RIA under basal conditions and in response to peptone meal stimulation. Acid secretion was measured under basal conditions and in response to peptone meal stimulation. Presence of H. pylori was detd. by both 14C-urea breath test and ELISA serol. Inhibition of gastric acid output by ranitidine bismuth citrate was both time- and dose-dependent over the 9-h post-dose study period. Doses of ranitidine bismuth citrate 400 mg and ranitidine hydrochloride 150 mg, which are equimolar, produced similar suppression of acid output regardless of H. pylori status. Ranitidine bismuth citrate had no effect on plasma gastrin concns. regardless of H. pylori status. All doses of ranitidine bismuth citrate were well tolerated. Ranitidine bismuth citrate caused time- and dose-dependent redns. in meal-stimulated and between-meal gastric acid output regardless of H. pylori status. 9002-76-0 and 128345-62-0 are just another two chemicals used in this study. The magnitude of decreased acid secretion was similar with ranitidine bismuth citrate 400 mg and ranitidine hydrochloride 150 mg. Ranitidine bismuth citrate had no effect on plasma gastrin concns. .