Detail of "128917-74-8"

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Synthesis of Amphiphilic Guanylated Polymers as Potential Gene Delivery Carriers

Synthesis of Amphiphilic Guanylated Polymers as Potential Gene Delivery Carriers. Sharma, Sunil K.; Sharma, Ajendra K.; Samuelson, Lynne A.; Kumar, Jayant; Watterson, Arthur C.; Parmar, Virinder S. (Department of Chemistry, Institute for Nano-Science and Engineering Technology, University of Massachusetts, Lowell, MA, USA). Journal of Macromolecular Science, Pure and Applied Chemistry, A41(12), 1459-1466 (English) 2004 Marcel Dekker, Inc. CODEN: JSPCE6. ISSN: 1060-1325. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) We have developed novel polymeric systems that aggregate in aq. media to form nanospheric particles. Our polymeric system constitutes guanidine functional groups and poly(ethylene glycol) (PEG) units. The guanidine group is an important structural component in many biol. active compds. Because of their strongly basic character, guanidines are fully protonated under physiol. conditions. The pos. charge thus imposed on the mol. forms the basis for specific interactions between the ligand and receptor or the enzyme and substrate. The PEG units may form a characteristic micelle structure with a hydrophilic shell layer surrounding the core of the polyion complex (PIC) formed between DNA and the cation segments (PIC micelles).Except for chemicals metioned above, 128917-74-8 and 824431-13-2 are also used. .