Reference

Method for binding hydrohpihlic substances to fine carbon fibers

Method for binding hydrohpihlic substances to fine carbon fibers. Kurita, Tomotaka; Kohama, Hiromasa (Terumo Corp., Japan). Jpn. Kokai Tokkyo Koho JP 2006036638 A2 9 Feb 2006, 11 pp. (Japanese). (Japan). CODEN: JKXXAF. APPLICATION: JP 2004-213842 22 Jul 2004. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) The invention relates to a process for binding a hydrophilic substance, e.g. a drug or a imaging agent, to fine carbon fiber, e. 129332-29-2 which is the cas registry number is also used here.g.Several substances like 129332-29-2 may be metioned in this study. carbon nanofiber, carbon nanotube, and carbon nanohorn, etc. as drug carrier, wherein the method includes protecting hydrophilic group of the substance, dissolving the hydrophobilized substance in subcrit. or supercrit. fluid and binding them to fine carbon fiber, and deprotecting the substance. For example, doxorubicin hydrochloride was reacted with di-tert-Bu dicarbonate to form N-Boc doxorubicin. The N-Boc doxorubicin was dissolved in supercrit. carbon dioxide fluid with multilayered carbon fiber. Then, the carbon fiber was mixed with HCl/acetic acid soln., and dried to give doxorubicin hydrochloride-bound carbon fiber. ..

Method for binding hydrohpihlic substances to fine carbon fibers

Method for binding hydrohpihlic substances to fine carbon fibers. Kurita, Tomotaka; Kohama, Hiromasa (Terumo Corp., Japan). Jpn. Kokai Tokkyo Koho JP 2006036638 A2 9 Feb 2006, 11 pp. (Japanese). (Japan). CODEN: JKXXAF. APPLICATION: JP 2004-213842 22 Jul 2004. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) The invention relates to a process for binding a hydrophilic substance, e.g. a drug or a imaging agent, to fine carbon fiber, e. 129332-29-2 which is the cas registry number is also used here.g.Several substances like 129332-29-2 may be metioned in this study. carbon nanofiber, carbon nanotube, and carbon nanohorn, etc. as drug carrier, wherein the method includes protecting hydrophilic group of the substance, dissolving the hydrophobilized substance in subcrit. or supercrit. fluid and binding them to fine carbon fiber, and deprotecting the substance. For example, doxorubicin hydrochloride was reacted with di-tert-Bu dicarbonate to form N-Boc doxorubicin. The N-Boc doxorubicin was dissolved in supercrit. carbon dioxide fluid with multilayered carbon fiber. Then, the carbon fiber was mixed with HCl/acetic acid soln., and dried to give doxorubicin hydrochloride-bound carbon fiber. ..