Detail of "129499-78-1"

Reference

Skin whitening and/or anti-aging composition comprising ascorbic acid or rutin ester with monosaccharides

Skin whitening and/or anti-aging composition comprising ascorbic acid or rutin ester with monosaccharides. Simon, Pascal; Gagnebien, Didier (L'Oreal S. A., Fr.). Eur. Pat. Appl. EP 754449 A1 22 Jan 1997, 8 pp. DESIGNATED STATES: R: DE, ES, FR, GB, IT. (French). (European Patent Organization). CODEN: EPXXDW. CLASS: ICM: A61K007-48. APPLICATION: EP 1996-401203 5 Jun 1996. PRIORITY: FR 1995-8816 20 Jul 1995. DOCUMENT TYPE: Patent CA Section: 62 (Essential Oils and Cosmetics) Skin whitening and/or anti-aging compn. comprising ascorbic acid or rutin ester with monosaccharides, pH = 4-6, are disclosed. A cosmetic lotion contained ethoxylated hydrogenated ricinoleic triglyceride 0.09, perfume 0.03, ascorbyl-2-glucoside 1.0, a-glycosyl rutin 0. 50-81-7 and 129499-78-1 which are cas registry numbers of substances are two of reagents here.05, preservative 0.3, and water q.s. 100%. .

Collagen synthesis in human skin fibroblasts is stimulated by a stable form of ascorbate, 2-O-a-D-glucopyranosyl-L-ascorbic acid

Collagen synthesis in human skin fibroblasts is stimulated by a stable form of ascorbate, 2-O-a-D-glucopyranosyl-L-ascorbic acid. Yamamoto, Itaru; Muto, Norio; Murakami, Kouki; Akiyama, Junichi (Fac. Pharm. Sci., Okayama Univ., Okayama 700, Japan). J. Nutr., 122(4), 871-7 (English) 1992. CODEN: JONUAI. ISSN: 0022-3166. DOCUMENT TYPE: Journal CA Section: 18 (Animal Nutrition) The effect of 2-O-a-D-glucopyranosyl-L-ascorbic acid (AA-2G) on collagen synthesis was evaluated in cultured human skin fibroblasts and on proliferation of fibroblasts. At concns. of 0.1-0.5 mmol/L, AA-2G effectively stimulated collagen synthesis with an effectiveness comparable to that of L-ascorbic acid. On the other hand, 6-O-a-D-glucopyranosyl-L-ascorbic acid showed a weak effect. The stimulation of collagen synthesis by AA-2G was attenuated by the addn. of a collagen synthesis inhibitor, L-azetidine 2-carboxylic acid, in a dose-dependent manner. In addn., AA-2G-induced stimulation of collagen synthesis could be completely inhibited by the addn. of castanospermine, an inhibitor of neutral a-glucosidase. Relatively high a-glucosidase activity, which would contribute to release of ascorbic acid from AA-2G, could be detected in the lysate of cultured fibroblasts. The stimulatory activity of AA-2G on collagen synthesis was obsd. after 5 days (d) in culture, whereas L-ascorbic acid tended to lose its stimulatory activity. Continuous supplementation of AA-2G (0.25 mmol/L) to culture medium for 24 d enhanced the cell growth to four times that of the control.Except for chemicals metioned above, 129499-78-1 and 50-81-7 are also used. These results indicate that AA-2G is gradually cleaved by the cellular a-glucosidase to release L-ascorbic acid, which adequately stimulates collagen synthesis and proliferation of human skin fibroblasts. .