Detail of "13019-22-2"

Reference

Stable liposomes with aqueous-soluble medicaments

Stable liposomes with aqueous-soluble medicaments. Felgner, Philip L.; Eppstein, Deborah A. (Syntex (U.S.A.In this study，13019-22-2 is also used.), Inc., USA). Eur. Pat. Appl. EP 172007 A2 19 Feb 1986, 47 pp. DESIGNATED STATES: R: AT, BE, CH, DE, FR, GB, IT, LI, LU, NL, SE. (European Patent Organization) CODEN: EPXXDW. CLASS: ICM: A61K009-50. ICS: A61K045-02. APPLICATION: EP 85-305672 9 Aug 1985. PRIORITY: US 84-639638 10 Aug 1984; US 85-739729 31 May 1985. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Liposomes were prepd. from lipids R1OCH2CH(OR2)(CH2)nN+R3R4R5 X- (R1, R2= C6-22 alkyl or alkenyl; R3, R4, R5 = OH, C1-8 alkyl, C7-11 aralkyl; n = 1-8, X = a pharmaceutically acceptable anion), other nonphosphorus-contg. lipids such as stearylamine, glycerol ricinoleate, amphoteric acrylic polymers, and the like, or phospholipids, which were dissolved in a solvent (suitable for freeze drying) and the soln. was subjected to lyophilization. The resulting lyophilized lipid was hydrated with an aq. soln. of a water-sol. medicament. Thus, diarachidoylphosphatidylcholine (DAPC) and dipalmitoylphosphatidylglycerol (DPPG), 7:3 molar ratio, were dissolved in CHCl3. The soln. was dried to a film under N and placed under vacuum for 30 min. A portion (20 mmol) of the dried lipids was then dissolved in cyclohexane, frozen, and the solvent removed by lyophilization. The lyophilized lipids were hydrated with an aq. soln. of human b-interferon. The formulation may also contain stabilizers (dextrose, human serum albumin) and buffers. The interferon-contg. liposomes are suitable for topical application by nasal drops, aerosols, or suppositories. The liposomes are more stable, have a higher capture efficiency, and are more easily prepd. than known liposomes. .

Preparation of fluorine-containing succinic acid esters and water repellents containing them

Preparation of fluorine-containing succinic acid esters and water repellents containing them. Sato, Tomoe; Onodera, Seiichi (Sony Corp., Japan). Jpn. Kokai Tokkyo Koho JP 2004035513 A2 5 Feb 2004, 9 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: ICM: C07C069-63. ICS: C07C069-65; C09K003-18. APPLICATION: JP 2002-197962 5 Jul 2002. DOCUMENT TYPE: Patent CA Section: 23 (Aliphatic Compounds) Section cross-reference(s): 35, 42 R1CH(COOR2)CH2COOR3 (I; R1 = alkyl, alkenyl, H; R2, R3 = fluoroalkyl, fluoroalkenyl, fluoropolyether, H) and water repellents contg. I are claimed. I show good dissoln. in solvents such as lower alcs. and high affinity to surface to be coated, and are useful for car wax, antisoiling agents for exterior walls, and waterproofing agents for tents, hoods for vehicles, umbrellas, etc. Thus, refluxing a mixt. of 15.6 g CH2:CH(CH2)8OH, 54.6 g F(CH2)8I, and AIBN for 8 h gave 56 g F(CH2)8CH2CHI(CH2)8OH, which was dissolved in EtOH, treated with HCl and Zn under reflux for 3 h, and worked up to give 37 g F(CH2)8CH2CH2(CH2)8OH. 13019-22-2 and 443126-45-2 which are cas registry numbers of substances are two of reagents here. This was reacted with isooctadecylsuccinic anhydride and H2SO4 in toluene under reflux for 3 h to give 43 g C9H19CH(C7H15)CH2CH(CO2C10H20C8F17)CH2CO2C10H20C8F17 (II). An EtOH soln. of II was spread over a glass plate, dried, and rubbed with absorbent cotton to form a film. Water repellency of the film was not changed even after 3-mo storage at 60° and relative humidity 90%. .