Detail of "13031-76-0"

Reference

Biotransformation and quantitative determination of sulfur-containing metabolites of 1,4-dibromobutane in the rat

Biotransformation and quantitative determination of sulfur-containing metabolites of 1,4-dibromobutane in the rat. Onkenhout, W.; Van Loon, W.Several substances are used for example 110-52-1 which is its cas registry number. M. G. M.; Buijs, W.; Van der Gen, A.; Vermeulen, N. P. E. (Dep. Pharm. Anal., Univ. Leiden, Amsterdam 1081 HV, Neth.). Drug Metab. Dispos., 14(5), 608-12 (English) 1986. CODEN: DMDSAI. ISSN: 0090-9556. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Two stable S-contg. metabolites were isolated from rat urine following the administration of the mutagenic 1,4-dibromobutane [110-52-1]. They were identified as tetrahydrothiophene [110-01-0] and 3-hydroxysulfolane [13031-76-0] by gas chromatog. and gas chromatog.-mass spectrometry and were excreted in 48-h urine, representing 5.8 and 57% of the dose of 1,4-dibromobutane, resp. When urines of rats treated with 1,4-dibromobutane were collected in a buffer of pH 1.0, however only 3-hydroxysulfolane was found. It was indirectly shown that N-acetyl-S-(b-alanyl)tetrahydrothiophenium [105878-47-5] was present in urine and that this metabolite is probably the precursor of tetrahydrothiophene. The latter product is only formed at higher pH values and quantified after the addn. of NaOH to buffered urines. Tetrahydrothiophene is probably also formed under physiol. conditions in vivo from the N-acetyl-S-(b-alanyl)-tetrahydrothiophenium salt, but in this case it is subsequently transformed to 3-hydroxysulfolane. Based on these findings, a biotransformation scheme of 1,4-dibromobutane in the rat is proposed. The extensive metab. via glutathione conjugation resulted in efficient detoxification of 1,4-dibromobutane. .

LC/MS determination of a sulfolane metabolite in wetland vegetation exposed to sour gas-contaminated groundwater

LC/MS determination of a sulfolane metabolite in wetland vegetation exposed to sour gas-contaminated groundwater. Headley, J. V.; Peru, K. M. (NWRI, AEPRB, Environment Canada, Saskatoon, Can.). Advances in Mass Spectrometry, 15, 869-870 (English) 2001 John Wiley & Sons Ltd. CODEN: AMSPAH. ISSN: 0568-000X. DOCUMENT TYPE: Journal CA Section: 61 (Water) Section cross-reference(s): 11, 80 A reverse-phase LC electrospray ionization MS method is described that was used to investigate the degrdn. of sulfolane to 3-hydroxysulfolane in wetland vegetation. Preliminary MS expts. showed that adduct ions could be used for quantification. The results of the anal. for the vegetation, soil, and water indicated that for samples where the levels of sulfolane are elevated in the vegetation, there was evidence of the transformation product at levels above the concn. is obsd. for soil and groundwater.Except for chemicals metioned above, 7732-18-5 and 13031-76-0 are also used. .