Reference

In vitro anticoagulant-antacid interactions

In vitro anticoagulant-antacid interactions. Khalil, Said A.; Naggar, Viviane F.; Zaghloul, Iman A.; Ismail, Assem A. (Fac. Pharm., Univ. Alexandria, Alexandria, Egypt). Int. J. Pharm., 19(3), 307-21 (English) 1984. CODEN: IJPHDE. ISSN: 0378-5173. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) The adsorption characteristics of oral anticoagulants on some selected antacids were studied. The indandione anticoagulants used were: phenindione [83-12-5] and diphenadione [82-66-6] while the coumarin anticoagulants tested were: dicoumarol [66-76-2], Et biscoumacetate [548-00-5], nicoumalone [152-72-7], phenprocoumon [435-97-2] and warfarin [81-81-2]. The antacids or adsorbents used were: Al glycinate [13682-92-3], Al(OH)3, Bi carbonate, Bi salicylate [19034-57-2], Bi subgallate [99-26-3], Bi subnitrate [1304-85-4], CaCO3, charcoal, dihydroxyaluminium sodium carbonate [12011-77-7], magaldrate [74978-16-8], Mg trisilicate and kaolin. Adsorption of phenindione was significant on charcoal and MgO. Al(OH)3, Bi carbonate, subnitrate and salicylate adsorbed phenindione to a lesser extent. Other substances showed relative weak adsorption properties. Diphenadione, on the other hand, was adsorbed on most substances tested. The extent of dicoumarol adsorbed was quite high on Bi carbonate, salicylate and subnitrate as well as on MgO. It was intermediate on Al glycinate and magaldrate. The amt. of the anticoagulant adsorbed on Al(OH)3, Bi subgallate and Mg trisilicate, under the exptl. conditions, was quite low. Glycine decreased the amt. of dicoumarol adsorbed on Bi carbonate and to a lower extent on MgO, while it had a negligible effect on the amt. adsorbed on Bi subnitrate. The other coumarin derivs. showed no or very low adsorption tendencies for the substances tested, with the exception of charcoal, Bi subnitrate and salicylate. The dissoln. of phenindione decreased in the presence of the adsorbing substances esp. in acidic medium. The dissoln. of dicoumarol in the presence of MgO was also decreased.

Prevention of lethal and renal toxicity of cis-diamminedichloroplatinum(II) by induction of metallothionein synthesis without compromising its antitumor activity in mice

Prevention of lethal and renal toxicity of cis-diamminedichloroplatinum(II) by induction of metallothionein synthesis without compromising its antitumor activity in mice.Some chemicals with cas registry numbers like 1304-85-4 and 15663-27-1 are also used. Naganuma, Akira; Sato, Masahiko; Imura, Nobumasa (Sch. Pharm. Sci., Kitasato Univ., Tokyo 108, Japan). Cancer Res., 47(4), 983-7 (English) 1987. CODEN: CNREA8. ISSN: 0008-5472. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The participation of renal metallothionein (MT) in the toxicity and antitumor activity of cis-diamminedichloroplatinum(II) (cis-DDP) [15663-27-1] in male mice was examd. Preinduction of MT in the kidney by the s.c. administration of bismuth compds. decreased the lethality and renal and gastrointestinal toxicity caused by a single s.c. injection of cis-DDP. A correlation between the protective effect of pretreatment with bismuth nitrate against cis-DDP toxicity and the preinduced MT levels in the kidney was obsd. Bismuth nitrate pretreatment showed no effect on the antitumor activity of cis-DDP against several transplantable tumors, probably because it induces MT in the kidney but not in tumor tissues. The fact that p.o. preadministration of bismuth subnitrate, an antidiarrheal drug, also depressed the lethal toxicity of cis-DDP is promising for its prompt application in medical attention. Thus, bismuth pretreatment allows higher doses of cis-DDP with no apparent toxicity, resulting in more efficient utilization of this anticancer drug. .