Detail of "13057-72-2"

Reference

Hydroxyisoflavones for treatment of osteoporosis

Hydroxyisoflavones for treatment of osteoporosis. Yamazaki, Iwao; Sawa, Yoichi (Takeda Chemical Industries, Ltd. , Japan). Ger. Offen. DE 3430799 A1 14 Mar 1985, 13 pp. (German). (Germany). CODEN: GWXXBX. CLASS: ICM: A61K031-35. APPLICATION: DE 84-3430799 22 Aug 1984. PRIORITY: JP 83-155603 24 Aug 1983. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 2 I (R = H or OH), in combination with pharmaceutically suitable carriers, diluents, and lubricants are used for prevention or treatment of osteoporosis. I have milder estrogenic activity than conventional estrogens, and can treat osteoporosis and stimulate calcitonin secretion by the thyroid. Tablets (1000) were prepd. from 7-hydroxyisoflavone [13057-72-2] 200, lactose 15, starch 44, Na CM-cellulose 10, and Mg stearate 1 g. The estrogenic activity was demonstrated in young oophorectomized rats, and the inhibition of bone resorption in cultures of rat fetal bone. I also inhibited parathormone [9002-64-6]-stimulated bone resorption in fetal rat bone cultures. The compds. were not toxic to rats at 10,000 mg/kg orally in olive oil or 5000 mg/kg s.c. The recommended oral dose in humans is 5-20 mg/kg/day.

Isoflavones for treating ovarian insufficiency

Isoflavones for treating ovarian insufficiency. Yamazaki, Iwao; Sawa, Yoichi (Takeda Chemical Industries, Ltd. , Japan). Ger. Offen. DE 3415394 A1 31 Oct 1984, 12 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: A61K031-35. APPLICATION: DE 84-3415394 25 Apr 1984. PRIORITY: JP 83-74575 26 Apr 1983. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 2 I, where R is H or lower alkyl, can be administered in tablet, granular, capsular, powder, or syrup form to treat ovarian insufficiency, climacteric disturbances, or infertility. Expts. in oophorectomized rats showed that 7-hydroxyisoflavone [13057-72-2] and 7-isopropyloxyisoflavone [35212-22-7] potentiated the activity of coadministered estrone. Tablets were prepd. from 7-isopropyloxyflavone 200, lactose 15, starch 44, ECG-500 10, and Mg stearate 1 g.