Detail of "130663-39-7"

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Lack of a beneficial effect of PD123319, an AT2-angiotensin receptor antagonist, on the course of ablation nephropathy in the rat

Lack of a beneficial effect of PD123319, an AT2-angiotensin receptor antagonist, on the course of ablation nephropathy in the rat.Several substances are used for example 60-27-5 and 130663-39-7 which are their cas registry numbers. Cervenka, L.; Heller, J.; Jelinek, F. (Inst. Clinical Experimental Medicine, Prague 14000, Czech Rep.). Kidney & Blood Pressure Research, 19(5), 241-244 (English) 1996 Karger. CODEN: KBPRFC. ISSN: 1420-4096. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Rats underwent a surgical ablation of 5/6 of their renal parenchyma were treated for 8 wk with the angiotensin II AT1-receptor antagonist losartan (L), with the AT2-receptor antagonist PD123319 (PD), or with L + PD. Treatment with L resulted in a higher survival rate and creatinine clearance as well as in lower blood pressure, proteinuria and glomerulosclerosis score. Cardiac and kidney remnant hypertrophy was completely abolished by L, and plasma renin activity was elevated only in L groups. .

Systemic and renal hemodynamic effects of the AT1 receptor antagonist, ZD 7155, and the AT2 receptor antagonist, PD 123319, in conscious lambs

All Rights Reserved. Systemic and renal hemodynamic effects of the AT1 receptor antagonist, ZD 7155, and the AT2 receptor antagonist, PD 123319, in conscious lambs. Chappellaz, Mona L.; Smith, Francine G. (Departments of Physiology & Biophysics/Medicine, University of Calgary, Calgary, AB T2N 4N1, Can.).Some commonly used reagents like 146709-78-6 and 130663-39-7 are used in this experiment. Pfluegers Archiv, 453(4), 477-486 (English) 2007 Springer GmbH. CODEN: PFLABK. ISSN: 0031-6768. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Expts. were carried out to investigate age- and dose-dependent effects of the selective AT1 receptor antagonist, ZD 7155, and the selective AT2 receptor antagonist, PD 123319, on systemic and renal hemodynamics in conscious, chronically instrumented lambs aged ~1 and ~6 wk of postnatal life. Mean arterial pressure (MAP), mean venous pressure (MVP), and renal blood flow (RBF) were measured for 10 min before and for 120 min after ZD 7155, PD 123319, or vehicle. In both age groups, administration of ZD 7155 decreased renal vascular resistance (RVR) and increased RBF within 5 min. These responses lasted less than 90 min but were not dose-dependent. MAP decreased by 30 min after administration of ZD 7155 in both age groups at doses 3400 mg kg-1; the remaining decreased for up to 120 min, depending upon the dose. Pressor responses to angiotensin II (ANG II) were abolished within 5 min of administration of all doses of ZD 7155, at both 1- and 6 wk. PD 123319 had no detectable effects on systemic or renal hemodynamics or on the pressor responses to ANG II. Therefore, under physiol. conditions in conscious newborn animals, ANG II modulates both resting blood pressure and RVR through activation of AT1 but not AT2 receptors. .