Detail of "131-73-7"

Reference

Compression characteristics of sodium chloride, potassium chloride and hexamethylenetetramine

Compression characteristics of sodium chloride, potassium chloride and hexamethylenetetramine. Jetzer, W.; Leuenberger, H. (Pharm. Inst., Univ. Basel, Basel CH-4051, Switz.). Powder Technol., 42(2), 137-44 (German) 1985. CODEN: POTEBX. ISSN: 0032-5910. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Deformation hardness P of a powder compact increases under compression stress (sc according to the following equation: P = Pmax[1 - exp(-gscrr)], where Pmax is the max. possible hardness at sc ? ￥, g is the compression susceptibility parameter and rr is the relative d. with rr = 1 - e, e = porosity of the compact. In the case of easily deformable powder material the deformation hardness P already approxs. at medium pressures sc the max. possible value Pmax (e.g., aspirin [50-78-2]). In contrast to the abovementioned material, NaCl, KCl, and hexamine [131-73-7] form, under pressure, semitransparent or completely transparent compacts. Contrary to the abovementioned equation, the deformation hardness P passes through a max. value and decreases at higher pressure. This decrease can be partly related to the remaining solvent content of the powder compressed, which originates from the crystn. procedure. A decrease in deformation hardness is due to a work-softening effect, i.e., to a decrease of lattice defects in the polycryst. compact under the applied pressure.

Drug permeation through synthetic lipid membranes

Drug permeation through synthetic lipid membranes. Part 17: mechanism of ion pair permeation. Neubert, R.; Fuerst, W.; Boehm, W.; Dabow, Sabine (Sekt. Pharm., Martin-Luther-Univ., Halle/Saale, Ger. Dem. Rep.). Pharmazie, 39(6), 401-3 (German) 1984. CODEN: PHARAT. ISSN: 0031-7144. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 63 The effects of lipophilic counterions on the transport of the ionized drugs buformin (I) [692-13-7], neostigmine (II) [59-99-4], pholedrine [370-14-9], and cromoglycic acid [16110-51-3] across lipid membranes were studied. The partition coeffs. of I and II were detd. in the presence of various counterions. The effects of dipicrylamine [131-73-7], Na lauryl sulfate [151-21-3], bromcresol green [76-60-8], and benzalkonium bromide on the lipid membrane transport of the ionized drugs were studied. Apparently, highly lipophilic counterions accumulate in the lipid membrane and act as a carrier for the ionized drugs.